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851010 PyBroP

PyBroP Novabiochem®. CAS 132705-51-2, molar mass 466.19 g/mol.

PyBroP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 132705-51-2 Molar Mass: 466.19 g/mol Hill Formula: C₁₂H₂₄BrN₃P * F₆P
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851010
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
132705-51-2C₁₂H₂₄BrN₃P * F₆P466.19 g/mol
Description
Catalogue Number851010
Replaces01-62-0017
Brand Family Novabiochem®
Alternate Names
  • Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate
Background InformationA superior reagent for rapid and effective coupling of N-methyl amino acids with low enantiomerization and for other critical applications [1-8].

The coupling of N-methyl amino acids is difficult, and usually only gives low to moderate yields of products which are often contaminated with unwanted diastereomers. Many coupling reagents are ineffective or not practical to use: BOP and HOBt are often useless; BOP-Cl, pivaloyl chloride and Dpp-Cl require long reaction times and preactivation at 0°C.

For coupling α-aminoisobutyric acid (Aib), PyBroP® is most effective when used with dimethylaminopyridine (DMAP) [3].

The product number for this product was previously 01-62-0017.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
References
Product Information
CAS number132705-51-2
Hill FormulaC₁₂H₂₄BrN₃P * F₆P
Molar Mass466.19 g/mol
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationPyBroP Novabiochem®. CAS 132705-51-2, molar mass 466.19 g/mol.
Biological Information
Physicochemical Information
Melting Point>100 °C
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Hazard Pictogram(s) Hazard Pictogram(s)
Hazard Statement(s)H314: Causes severe skin burns and eye damage.
Precautionary Statement(s)P260: Do not breathe dust.
P280: Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.
P303 + P361 + P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P304 + P340 + P310: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P363: Wash contaminated clothing before reuse.
Signal WordDanger
Storage class8A Combustible, corrosive hazardous materials
WGKWGK 3 highly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Declaration (railroad and road) ADR, RIDUN 3261 , 8, II
Declaration (transport by air) IATA-DGRUN 3261 , 8, II
Declaration (transport by sea) IMDG-CodeUN 3261 , 8, II, Segregation Group: 1 (Acids)
Supplemental Information
Specifications
Color (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Assay (HPLC, area%)≥ 98.0 % (a/a)

Documentation

PyBroP SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] J. Coste, et al. in 'Peptides, Chemistry, Structure & Biology, Proc. 11th American Peptide Symposium', J. E. Rivier & G. R. Marshall (Eds), ESCOM, Leiden, 1990, pp. 900.
  • [2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 669.
  • [3] J. Coste, et al. in 'Peptides 1990, Proc. 21st European Peptide Symposium', E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp. 76.
  • [4] J. Coste, et al. (1991) Tetrahedron Lett., 32, 1967.
  • [5] P. W. Baures, et al. (1997) J. Peptide Res., 50, 1.
  • [6] T. Doi, et al. (1999) Synlett, 11, 1751.
  • [7] A. M. Boldi, et al. (2001) J. Comb. Chem., 3, 367.
  • [8] S. Gazal, et al. (2001) J. Peptide Res., 58, 527.