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557322 RK-682, Streptomyces sp.

RK-682, Streptomyces sp. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Hexadecanoyl-5-hydroxymethyl-tetronic Acid

Primary Target: dephosphorylation activity of CD45
557322
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      154639-24-4C₂₁H₃₆O₅
      Description
      Overview

      This product has been discontinued.





      A specific and noncompetitive inhibitor of protein tyrosine phosphatase with limited cell-permeability. Inhibits dephosphorylation activity of CD45 (IC50 = 54 µM) and VHR (vaccinia H1-related; IC50 = 2 µM) in vitro. Inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea-pig hippocampal CA1 neurons.
      Catalogue Number557322
      Brand Family Calbiochem®
      Synonyms3-Hexadecanoyl-5-hydroxymethyl-tetronic Acid
      References
      ReferencesFujii, S., et al. 1995. Neurosci. Lett. 187, 130.
      Fujii, S., et al. 1995. Neurosci. Lett. 187, 133.
      Hamaguchi, T., et al. 1995. FEBS Lett. 372, 54.
      Product Information
      CAS number154639-24-4
      FormPale yellow solid
      Hill FormulaC₂₁H₃₆O₅
      Chemical formulaC₂₁H₃₆O₅
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetdephosphorylation activity of CD45
      Primary Target IC<sub>50</sub>54 µM
      Secondary targetVHR (vaccinia H1-related; IC₅₀ = 2 µM) in vitro protein tyrosine phosphatase cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea-pig hippocampal CA1 neurons
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      557322 0

      Documentation

      RK-682, Streptomyces sp. Certificates of Analysis

      TitleLot Number
      557322

      References

      Reference overview
      Fujii, S., et al. 1995. Neurosci. Lett. 187, 130.
      Fujii, S., et al. 1995. Neurosci. Lett. 187, 133.
      Hamaguchi, T., et al. 1995. FEBS Lett. 372, 54.

      Brochure

      Title
      Protein Phosphatases Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms3-Hexadecanoyl-5-hydroxymethyl-tetronic Acid
      DescriptionA specific and noncompetitive inhibitor of protein tyrosine phosphatase with limited cell-permeability. Inhibits dephosphorylation activity of CD45 (IC50 = 54 µM) and VHR (vaccinia H1-related; IC50 = 2 µM) in vitro. Inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea-pig hippocampal CA1 neurons.
      FormPale yellow solid
      CAS number154639-24-4
      Chemical formulaC₂₁H₃₆O₅
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mg/ml) or ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFujii, S., et al. 1995. Neurosci. Lett. 187, 130.
      Fujii, S., et al. 1995. Neurosci. Lett. 187, 133.
      Hamaguchi, T., et al. 1995. FEBS Lett. 372, 54.