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559276 Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem

Ryanodine, High Purity - CAS 15662-33-6, is a naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum (IC50 = 10 nM for skeletal muscle).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Ca2+ transport and action in muscle
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559276
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
15662-33-6C₂₅H₃₅NO₉

Pricing & Availability

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559276-500UG
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      		 Plastic ampoule 500 μg
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      Description
      OverviewNaturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum. Has many complex effects on Ca2+ transport and action in muscle.
      Catalogue Number559276
      Brand Family Calbiochem®
      References
      ReferencesSorrentino, V., and Volpe, P. 1993. Trends Pharmacol. Sci. 14, 98.
      Sabbadini, R., et al. 1992. J. Biol. Chem. 267, 15475.
      Feher, J.J., and Lipford, G.B. 1985. Biochim. Biophys. Acta 813, 77.
      Marban, E., and Wier, W.G. 1985. Circ. Res. 56, 133.
      Sukto, J.L., et al. 1985. Fed. Proc. 44, 2984.
      Product Information
      CAS number15662-33-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₅H₃₅NO₉
      Chemical formulaC₂₅H₃₅NO₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationRyanodine, High Purity - CAS 15662-33-6, is a naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum (IC50 = 10 nM for skeletal muscle).
      Biological Information
      Primary TargetCa2+ transport and action in muscle
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSVM4025000
      Safety Information
      R PhraseR: 21/22-50/53

      Harmful in contact with skin and if swallowed.
      Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
      S PhraseS: 36/37-60-61

      Wear suitable protective clothing and gloves.
      This material and its container must be disposed of as hazardous waste.
      Avoid release to the environment. Refer to special instructions/safety data sheet.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      559276-500UG 04055977192353

      Documentation

      Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      559276

      References

      Reference overview
      Sorrentino, V., and Volpe, P. 1993. Trends Pharmacol. Sci. 14, 98.
      Sabbadini, R., et al. 1992. J. Biol. Chem. 267, 15475.
      Feher, J.J., and Lipford, G.B. 1985. Biochim. Biophys. Acta 813, 77.
      Marban, E., and Wier, W.G. 1985. Circ. Res. 56, 133.
      Sukto, J.L., et al. 1985. Fed. Proc. 44, 2984.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-December-2007 JSW
      DescriptionNaturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum. Has many complex effects on Ca2+ transport and action in muscle. Purified from Ryanodine Mixture.
      FormWhite solid
      CAS number15662-33-6
      RTECSVM4025000
      Chemical formulaC₂₅H₃₅NO₉
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityMethanol (20 mg/ml) or H₂O (1 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Toxicity Harmful
      Merck USA index14, 8307
      ReferencesSorrentino, V., and Volpe, P. 1993. Trends Pharmacol. Sci. 14, 98.
      Sabbadini, R., et al. 1992. J. Biol. Chem. 267, 15475.
      Feher, J.J., and Lipford, G.B. 1985. Biochim. Biophys. Acta 813, 77.
      Marban, E., and Wier, W.G. 1985. Circ. Res. 56, 133.
      Sukto, J.L., et al. 1985. Fed. Proc. 44, 2984.