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559406 SB 328437 - CAS 247580-43-4 - Calbiochem

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist.

SB 328437 - CAS 247580-43-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate

Primary Target: CC chemokine receptor-3 (CCR3)
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      247580-43-4C₂₁H₁₈N₂O₅
      Description
      OverviewA highly potent and selective CC chemokine receptor-3 (CCR3) antagonist. Inhibits calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4 with IC50 values of 38, 35, and 20 nM, respectively. Also inhibits eotaxin, eotaxin-2, and MCP-4-mediated chemotaxis (IC50 values: 32, 25, and 55 nM, respectively).
      Catalogue Number559406
      Brand Family Calbiochem®
      Synonyms(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
      References
      ReferencesWhite, J.R., et al. 2000. J. Biol. Chem. 275, 36626.
      Product Information
      CAS number247580-43-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₁H₁₈N₂O₅
      Chemical formulaC₂₁H₁₈N₂O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCC chemokine receptor-3 (CCR3)
      Primary Target IC<sub>50</sub>38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      559406 0

      Documentation

      SB 328437 - CAS 247580-43-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      White, J.R., et al. 2000. J. Biol. Chem. 275, 36626.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
      DescriptionA highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of 125I-eotaxin and 125I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC50 = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC50 = 38, 35, and 20 nM, respectively).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number247580-43-4
      Chemical formulaC₂₁H₁₈N₂O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWhite, J.R., et al. 2000. J. Biol. Chem. 275, 36626.