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407625 STAT3 Inhibitor XVI - CAS 1260364-43-9 - Calbiochem

The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IL-6 Inhibitor

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407625
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1260364-43-9C₂₁H₂₂N₂O₃S₃

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407625-5MG
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      Description
      OverviewA cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
      Catalogue Number407625
      Brand Family Calbiochem®
      SynonymsIL-6 Inhibitor
      References
      ReferencesZinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.
      Product Information
      CAS number1260364-43-9
      FormGrey solid
      Hill FormulaC₂₁H₂₂N₂O₃S₃
      Chemical formulaC₂₁H₂₂N₂O₃S₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407625-5MG 04055977211382

      Documentation

      STAT3 Inhibitor XVI - CAS 1260364-43-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      STAT3 Inhibitor XVI - CAS 1260364-43-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      407625

      References

      Reference overview
      Zinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.

      Brochure

      Title
      New Products: Volume 3, 2012
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-April-2012 JSW
      SynonymsIL-6 Inhibitor
      DescriptionA cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
      FormGrey solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1260364-43-9
      Chemical formulaC₂₁H₂₂N₂O₃S₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml; light pink/purple solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesZinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.