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563080 Salinomycin

Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug.

Salinomycin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
563080
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      53003-10-4C₄₂H₇₀O₁₁
      Description
      OverviewSalinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. In addition, global gene expression analyses show that salinomycin treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients.
      Catalogue Number563080
      Brand Family Calbiochem®
      References
      ReferencesGupta, P.B., et al. 2009. Cell. 138, 1.
      Product Information
      CAS number53003-10-4
      FormWhite to white with yellow cast
      Hill FormulaC₄₂H₇₀O₁₁
      Chemical formulaC₄₂H₇₀O₁₁
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 45

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      563080 0

      Documentation

      Salinomycin SDS

      Title

      Safety Data Sheet (SDS) 

      Salinomycin Certificates of Analysis

      TitleLot Number
      563080

      References

      Reference overview
      Gupta, P.B., et al. 2009. Cell. 138, 1.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-November-2019 JSW
      DescriptionSalinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. In addition, global gene expression analyses show that salinomycin treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients.
      FormWhite to white with yellow cast
      CAS number53003-10-4
      Chemical formulaC₄₂H₇₀O₁₁
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityMethanol (10 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      Merck USA index13, 8415
      ReferencesGupta, P.B., et al. 2009. Cell. 138, 1.