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569620 Stem Cell Proliferation Inhibitor

Stem Cell Proliferation Inhibitor MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-SDKP, Goralatide, Seraspenide

Primary Target: pluripotent hematopoietic stem cell proliferation
569620
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      127103-11-1C₂₀H₃₃N₅O₉
      Description
      Overview

      This product has been discontinued.





      A tetrapeptide that acts as a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Protects bone marrow against chemotherapeutic agents, ionizing radiations, hyperthermy, or phototherapy-induced toxicity. Inhibits cardiac fibroblast proliferation, collagen synthesis, and activation of p42/p44 MAP kinases. Cleaved to an inactive form by angiotensin I-converting enzyme (ACE).
      Catalogue Number569620
      Brand Family Calbiochem®
      SynonymsAc-SDKP, Goralatide, Seraspenide
      References
      ReferencesRhaleb, N.E., et al. 2001. Circulation 103, 3136.
      Gaudron, S., 1999. Stem Cells 17, 100.
      Masse, A., et al. 1998. Blood 91, 441.
      Rieger, K.J., et al. 1993. Biochem. J. 296, 373.
      Aizawa, S., et al. 1992. Exp. Hematol. 20, 896.
      Bonnet, D., et al. 1992. Exp. Hematol. 20, 251.
      Lenfant, M., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 779.
      Product Information
      CAS number127103-11-1
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₀H₃₃N₅O₉
      Chemical formulaC₂₀H₃₃N₅O₉
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Primary Targetpluripotent hematopoietic stem cell proliferation
      Secondary targetcardiac fibroblast proliferation, collagen synthesis, and activation of p42/p44 MAP kinases
      Purity≥97% by HPLC
      Physicochemical Information
      Peptide SequenceAc-Ser-Asp-Lys-Pro-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      569620 0

      Documentation

      Stem Cell Proliferation Inhibitor Certificates of Analysis

      TitleLot Number
      569620

      References

      Reference overview
      Rhaleb, N.E., et al. 2001. Circulation 103, 3136.
      Gaudron, S., 1999. Stem Cells 17, 100.
      Masse, A., et al. 1998. Blood 91, 441.
      Rieger, K.J., et al. 1993. Biochem. J. 296, 373.
      Aizawa, S., et al. 1992. Exp. Hematol. 20, 896.
      Bonnet, D., et al. 1992. Exp. Hematol. 20, 251.
      Lenfant, M., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 779.

      Brochure

      Title
      Stem Cell Resource Brochure GBP
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      SynonymsAc-SDKP, Goralatide, Seraspenide
      DescriptionA tetrapeptide that acts as a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Blocks the entry of hematopoietic stem cells into the cell cycle. It appears to be inactive on actively cycling cells and is only capable of maintaining quiescent cells in the G0 phase of the cell cycle. Reported to protect bone marrow against chemotherapeutic agents, ionizing radiations, hyperthermia, or phototherapy-induced toxicity in mice. Also reported to inhibit cardiac fibroblast proliferation, collagen synthesis, and activation of p42/p44 MAPK activity. Shown to be cleaved to an inactive form by angiotensin-converting enzyme (ACE).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number127103-11-1
      Chemical formulaC₂₀H₃₃N₅O₉
      Peptide SequenceAc-Ser-Asp-Lys-Pro-OH
      Purity≥97% by HPLC
      SolubilityH₂O (2 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRhaleb, N.E., et al. 2001. Circulation 103, 3136.
      Gaudron, S., 1999. Stem Cells 17, 100.
      Masse, A., et al. 1998. Blood 91, 441.
      Rieger, K.J., et al. 1993. Biochem. J. 296, 373.
      Aizawa, S., et al. 1992. Exp. Hematol. 20, 896.
      Bonnet, D., et al. 1992. Exp. Hematol. 20, 251.
      Lenfant, M., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 779.