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579000 Tamoxifen Citrate - CAS 54965-24-1 - Calbiochem

Tamoxifen is a potent synthetic anti-estrogenic agent.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Estrogen Receptor Signaling Regulator I

Primary Target: PKC
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579000
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
54965-24-1C₂₆H₂₉NO · C₆H₈O₇

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579000-100MG
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      		 Glass bottle 100 mg
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      Description
      OverviewA potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.
      Catalogue Number579000
      Brand Family Calbiochem®
      SynonymsEstrogen Receptor Signaling Regulator I
      References
      ReferencesRohlff, C., et al. 1998. Prostate 37, 51.
      Couldwell, W.J., et al. 1994. FEBS Lett. 345, 43.
      Baltuch, G.H., et al. 1993. Neurosurgery 33, 495.
      Powis, G. 1991. Trends Pharmacol. Sci. 12, 188.
      Issandou, M., et al. 1990. Cancer Res. 50, 5845.
      O’Brian, C.A., et al. 1985. Cancer Res. 45, 2462.
      Product Information
      CAS number54965-24-1
      ATP CompetitiveN
      FormWhite to off-white powder
      Hill FormulaC₂₆H₂₉NO · C₆H₈O₇
      Chemical formulaC₂₆H₂₉NO · C₆H₈O₇
      HS Code2922 19 95
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>10 µM against protein kinase C
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSKH2387000
      Safety Information
      R PhraseR: 22-45-60-61-64

      Harmful if swallowed.
      May cause cancer.
      May impair fertility.
      May cause harm to the unborn child.
      May cause harm to breastfed babies.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      579000-100MG 04055977265934

      Documentation

      Tamoxifen Citrate - CAS 54965-24-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Tamoxifen Citrate - CAS 54965-24-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      579000

      References

      Reference overview
      Rohlff, C., et al. 1998. Prostate 37, 51.
      Couldwell, W.J., et al. 1994. FEBS Lett. 345, 43.
      Baltuch, G.H., et al. 1993. Neurosurgery 33, 495.
      Powis, G. 1991. Trends Pharmacol. Sci. 12, 188.
      Issandou, M., et al. 1990. Cancer Res. 50, 5845.
      O’Brian, C.A., et al. 1985. Cancer Res. 45, 2462.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsEstrogen Receptor Signaling Regulator I
      DescriptionA potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines.
      FormWhite to off-white powder
      CAS number54965-24-1
      RTECSKH2387000
      Chemical formulaC₂₆H₂₉NO · C₆H₈O₇
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityEthanol (5 mg/ml), Methanol (5 mg/ml), or sparingly soluble in H₂O
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 9048
      ReferencesRohlff, C., et al. 1998. Prostate 37, 51.
      Couldwell, W.J., et al. 1994. FEBS Lett. 345, 43.
      Baltuch, G.H., et al. 1993. Neurosurgery 33, 495.
      Powis, G. 1991. Trends Pharmacol. Sci. 12, 188.
      Issandou, M., et al. 1990. Cancer Res. 50, 5845.
      O’Brian, C.A., et al. 1985. Cancer Res. 45, 2462.