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650366 Tryptase, Human Lung

Tryptase, Human Lung MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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650366
  
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      Overview

      Replacement Information
      Description
      OverviewNative tryptase from human lung. Tryptase is a serine protease stored in mast cell granules. A tetrameric enzyme composed of four non-covalently bound subunits. Each subunit is reported to contain one active site. Reported to upregulate neoangiogenesis in carcinogenesis of the uterine cortex. Tryptase is also an important mediator of allergic reactions that activates G-protein-coupled receptors through proteolysis, thus amplifying histamine release.
      Catalogue Number650366
      Brand Family Calbiochem®
      References
      ReferencesBenitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
      He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
      Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
      Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that gives a change of 1 absorbance per min at 410 nm using N-benzoyl-Phe-Val-Arg-<i>p</i>NA as a substrate in 30 min at 25°C.
      EC number3.4.21.59
      FormLiquid
      FormulationIn 1 M NaCl, 50 mM NaOAc, 50 µM heparin, 0.05% NaN₃.
      Quality LevelMQ100
      Applications
      Biological Information
      SourcePrepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥50 U/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38-42/43

      Irritating to eyes, respiratory system and skin.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      650366 0

      Documentation

      Tryptase, Human Lung SDS

      Title

      Safety Data Sheet (SDS) 

      Tryptase, Human Lung Certificates of Analysis

      TitleLot Number
      650366

      References

      Reference overview
      Benitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
      He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
      Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
      Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-November-2021 JSW
      DescriptionNative tryptase from human lung. Tryptase is a serine protease stored in mast cell granules. A tetrameric enzyme composed of four non-covalently bound subunits. Each subunit is reported to contain one active site. Tryptase is an important mediator of allergic reactions that activates G-protein-coupled receptors through proteolysis, thus amplifying histamine release.
      FormLiquid
      FormulationIn 1 M NaCl, 50 mM NaOAc, 50 µM heparin, 0.05% NaN₃.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      EC number3.4.21.59
      Specific activity≥50 U/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that gives a change of 1 absorbance per min at 410 nm using N-benzoyl-Phe-Val-Arg-pNA as a substrate in 30 min at 25°C.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesBenitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
      He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
      Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
      Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.