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681637 Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III

Primary Target: Wee1 and Chk1
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      1177150-89-8C₂₀H₁₂N₂O₃ • H₂O
      Description
      Overview

      This product has been discontinued.



      A pyrrolocarbazole compound that acts as a potent and ATP-competitive inhibitor of checkpoint kinases Wee1 and Chk1 (IC50 = 97 nM and 47 nM, respectively). Inhibits PKC, Cdk4, or other CDKs only at much higher concentrations (IC50 = 3.4 µM, 3.75 µM, and >5 µM, respectively) and exhibits little effect against FGFR, PDGFR, or c-Src (IC50 >50 µM).
      Catalogue Number681637
      Brand Family Calbiochem®
      Synonyms4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III
      References
      ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
      Squire, C.J., et al. 2005. Structure 13, 541.
      Product Information
      CAS number1177150-89-8
      ATP CompetitiveY
      FormOrange solid
      Hill FormulaC₂₀H₁₂N₂O₃ • H₂O
      Chemical formulaC₂₀H₁₂N₂O₃ • H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetWee1 and Chk1
      Primary Target IC<sub>50</sub>97 nM and 47 nM against Wee1 and Chk1, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      681637 0

      Documentation

      Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      681637

      References

      Reference overview
      Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
      Squire, C.J., et al. 2005. Structure 13, 541.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III
      DescriptionA pyrrolocarbazole compound that acts as a potent and ATP-competitive inhibitor of checkpoint kinases Wee1 and Chk1 (IC50 = 97 nM and 47 nM, respectively). Inhibits PKC, Cdk4, or other CDKs only at much higher concentrations (IC50 = 3.4 µM, 3.75 µM, and >5 µM, respectively) and exhibits little effect against FGFR, PDGFR, or c-Src (IC50 > 50µM).
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1177150-89-8
      Chemical formulaC₂₀H₁₂N₂O₃ • H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or Ethanol (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
      Squire, C.J., et al. 2005. Structure 13, 541.