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681668 Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem

A cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: QS11, Wnt Pathway Activator II

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681668
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
944328-88-5C₃₆H₃₃N₅O₂

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      Description
      OverviewA cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).
      Catalogue Number681668
      Brand Family Calbiochem®
      SynonymsQS11, Wnt Pathway Activator II
      References
      ReferencesZhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.
      Product Information
      CAS number944328-88-5
      FormPale amber solid
      Hill FormulaC₃₆H₃₃N₅O₂
      Chemical formulaC₃₆H₃₃N₅O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      681668-5MG 04055977260267

      Documentation

      Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      681668

      References

      Reference overview
      Zhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      SynonymsQS11, Wnt Pathway Activator II
      DescriptionA cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).
      FormPale amber solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number944328-88-5
      Chemical formulaC₃₆H₃₃N₅O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesZhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.