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421050 (Z-LL)₂ Ketone - Calbiochem

A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.

(Z-LL)₂ Ketone - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone

Primary Target: Processing of the p-Prl signal peptide
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₄₃H₆₄N₆O₉
      Description
      OverviewA novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
      Catalogue Number421050
      Brand Family Calbiochem®
      Synonyms1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
      References
      ReferencesWeihofen, A., et al. 2002. Science 296, 2215.
      Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
      Product Information
      ATP CompetitiveN
      FormOff-white lyophilized solid
      Hill FormulaC₄₃H₆₄N₆O₉
      Chemical formulaC₄₃H₆₄N₆O₉
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProcessing of the p-Prl signal peptide
      Primary Target IC<sub>50</sub>~ 50 nM inhibiting the processing of the p-Prl signal peptide
      Puritysingle spot by TLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      421050 0

      Documentation

      (Z-LL)₂ Ketone - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      (Z-LL)₂ Ketone - Calbiochem Certificates of Analysis

      TitleLot Number
      421050

      References

      Reference overview
      Weihofen, A., et al. 2002. Science 296, 2215.
      Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-March-2009 RFH
      Synonyms1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
      DescriptionA novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
      FormOff-white lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₃H₆₄N₆O₉
      Peptide SequenceZ-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
      Puritysingle spot by TLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesWeihofen, A., et al. 2002. Science 296, 2215.
      Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.