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344036 cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

The cFMS Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 870483-87-7, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580

Primary Target: CFMS
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344036
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
870483-87-7C₂₀H₂₂N₄O₃

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344036-1MG
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      Description
      OverviewA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available.
      Catalogue Number344036
      Brand Family Calbiochem®
      Synonyms5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
      References
      ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
      Product Information
      CAS number870483-87-7
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₂₀H₂₂N₄O₃
      Chemical formulaC₂₀H₂₂N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCFMS
      Primary Target IC<sub>50</sub>30 nM against cFMS kinase activity
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344036-1MG 04055977195149

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      344036

      References

      Reference overview
      Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-June-2010 JSW
      Synonyms5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
      DescriptionA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number870483-87-7
      Chemical formulaC₂₀H₂₂N₄O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.