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324895 eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem

eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apoptosis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Sal

Primary Target: elF-2α
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      304475-63-6C₂₁H₁₇Cl₃N₄OS
      Description
      OverviewA cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 = ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 = ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. Also available as a 50 mM solution in DMSO (Cat. No. 324897).
      Catalogue Number324895
      Brand Family Calbiochem®
      SynonymsSal
      References
      ReferencesBoyce, M., et al. 2005. Science 307, 935.
      Product Information
      CAS number304475-63-6
      ATP CompetitiveN
      FormBeige solid
      Hill FormulaC₂₁H₁₇Cl₃N₄OS
      Chemical formulaC₂₁H₁₇Cl₃N₄OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetelF-2α
      Primary Target IC<sub>50</sub>3 µM preventing HSV replication both in Vero cells.
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324895 0

      Documentation

      eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      324895

      References

      Reference overview
      Boyce, M., et al. 2005. Science 307, 935.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      SynonymsSal
      DescriptionA cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380)). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number304475-63-6
      Chemical formulaC₂₁H₁₇Cl₃N₄OS
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBoyce, M., et al. 2005. Science 307, 935.