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533872 miR-122 Inhibitor, NSC5476 - CAS 5455-90-3 - Calbiochem

Selectively down-regulates both mature miR-122 and primary miR-122 intracellular levels and reduces HIV replication.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-[(4aR,8aS)-(Octahydroquinolin-1(2H)-ylsulfonyl)-1,2,3,4-tetrahydroquinoline, NSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4aR,8aS)-(Octahydro-1(2H)-quinolinylsulfonyl)-1,2,3,4-tetrahydroquinoline, pri-miR-122 Transcription Inhibitor, miR-122 Inhibitor

Primary Target: miR-122
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      5455-90-3C₁₈HN₂O₂S
      Description
      OverviewA cell-permeable trans-decahydroquinolinylsulfonamide compound that acts as a potent, selective, and reversible inhibitor of miR-122 (EC50 = 600 nM in Huh7 cells transfected with psiCHECK-miR122 reporter plasmid). Induces a 1,250% increase in the relative luciferase signal that is indicative of strong miRNA-122 inhibition. Displays very little activity towards miR-21. Shown to down regulate the levels of mature miR-122 (by 72%) and the primary miR-122 (down to 3%). Shown to reduce hepatitis C virus (HCV) replication in Huh7 cells (47% reduction at 10 µM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533872
      Brand Family Calbiochem®
      Synonyms6-[(4aR,8aS)-(Octahydroquinolin-1(2H)-ylsulfonyl)-1,2,3,4-tetrahydroquinoline, NSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4aR,8aS)-(Octahydro-1(2H)-quinolinylsulfonyl)-1,2,3,4-tetrahydroquinoline, pri-miR-122 Transcription Inhibitor, miR-122 Inhibitor
      DescriptionmiR-122 Inhibitor, NSC5476
      References
      ReferencesYoung, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
      Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.
      Product Information
      CAS number5455-90-3
      FormWhite solid
      Hill FormulaC₁₈HN₂O₂S
      Chemical formulaC₁₈HN₂O₂S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmiR-122
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      533872 0

      Documentation

      miR-122 Inhibitor, NSC5476 - CAS 5455-90-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Young, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
      Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2016 JSW
      Synonyms6-[(4aR,8aS)-(Octahydroquinolin-1(2H)-ylsulfonyl)-1,2,3,4-tetrahydroquinoline, NSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4aR,8aS)-(Octahydro-1(2H)-quinolinylsulfonyl)-1,2,3,4-tetrahydroquinoline, pri-miR-122 Transcription Inhibitor, miR-122 Inhibitor
      DescriptionA cell-permeable trans-decahydroquinolinylsulfonamide compound that downregulates the liver-specific microRNA miR-122 level and pri-miR-122 production in Huh7 cells (by 72% & 93%, respectively; 10 µM for 48 h) without interaction with pre-miR-123 or affecting cellular miR-21 level. Selectively prevents miR-122-, but not miR-21-, mediated reporter transcription blockage (10 µM for 48 h) and suppresses HCV replication (by 53%; 10 µM inhibitor added 4 h post H77c/H77c/QR/KR/FV/SI RNA transfection for 48 h) in Huh7 cultures without affecting Huh7 proliferation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5455-90-3
      Chemical formulaC₁₈HN₂O₂S
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYoung, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
      Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.