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506161 p38 MAP Kinase Inhibitor IX - CAS 630106-85-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(Isoazol-3-yl)-4-methyl-3-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)benzamide

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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      A cell-permeable pyrazolo-pyrimidine compound that acts as a potent ATP-binding pocket-targeting inhibitor against p38α MAP kinase activity (IC50 = 5 nM; Ki = 0.2 nM), while exhibiting little or no activity against a panel of 21 other commonly studied kinases and 5 CYP 450 isozymes (IC50 ≥40 µM). Shown to be orally active in mice with excellent pharmacokinetics and in vivo efficacy in lowering (>70%; 5 mg/kg p.o. 5 h prior to LPS challenge) LPS-induced plasma TNFα production.
      Catalogue Number506161
      Brand Family Calbiochem®
      SynonymsN-(Isoazol-3-yl)-4-methyl-3-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)benzamide
      References
      ReferencesDas, J., et al. 2008. Bioorg. Med. Chem. Lett. 18, 2652.
      Product Information
      CAS number630106-85-3
      FormOff-white solid
      Hill FormulaC₂₂H₁₇N₇O₂
      Chemical formulaC₂₂H₁₇N₇O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      506161 0

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      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      p38 MAP Kinase Inhibitor IX - CAS 630106-85-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Das, J., et al. 2008. Bioorg. Med. Chem. Lett. 18, 2652.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2011 RFH
      SynonymsN-(Isoazol-3-yl)-4-methyl-3-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)benzamide
      DescriptionA cell-permeable pyrazolo-pyrimidine compound that acts as a potent ATP-binding pocket-targeting inhibitor against p38α MAP kinase activity (IC50 = 5 nM; Ki = 0.2 nM), while exhibiting little or no activity against a panel of 21 other commonly studied kinases and 5 CYP 450 isozymes (IC50 ≥40 µM). Shown to be orally active in mice with excellent pharmacokinetics and in vivo efficacy in lowering (>70%; 5 mg/kg p.o. 5 h prior to LPS challenge) LPS-induced plasma TNFα production.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number630106-85-3
      Chemical formulaC₂₂H₁₇N₇O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDas, J., et al. 2008. Bioorg. Med. Chem. Lett. 18, 2652.