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672152 uPA Inhibitor II, UK122 - Calbiochem

The uPA Inhibitor II, UK122 controls the biological activity of uPA. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

uPA Inhibitor II, UK122 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-((5-Oxo-2-phenyl-4(5H)-oxazolylidene)methyl)benzenecarboximidamide, trifluoroacetate

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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₇H₁₃N₃O₂ • CF₃CO₂H
      Description
      OverviewA cell-permeable oxazolidinone-carboxamidine compound that acts as a potent, selective, and active-site targeting inhibitor of urokinase-type plasminogen activator (uPA; IC50 = 200 nM) with much reduced activity against trypsin, thrombin, tPA, and plasmin (38%, 8%, 5%, and 0% inhibition, respectively, with 100 µM UK122). Shown to effectively inhibit the migration and invasion (80% and 68% inhibition, respectively, with 100 µM UK122), but not proliferation, of uPA-expressing CFPAC-1 pancreatic cells.
      Catalogue Number672152
      Brand Family Calbiochem®
      Synonyms4-((5-Oxo-2-phenyl-4(5H)-oxazolylidene)methyl)benzenecarboximidamide, trifluoroacetate
      References
      ReferencesZhu, M., et al. 2007. Mol. Cancer Ther. 6, 1348.
      Product Information
      FormYellow solid
      Hill FormulaC₁₇H₁₃N₃O₂ • CF₃CO₂H
      Chemical formulaC₁₇H₁₃N₃O₂ • CF₃CO₂H
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      672152 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      uPA Inhibitor II, UK122 - Calbiochem Certificates of Analysis

      TitleLot Number
      672152

      References

      Reference overview
      Zhu, M., et al. 2007. Mol. Cancer Ther. 6, 1348.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-Febuary-2009 RFH
      Synonyms4-((5-Oxo-2-phenyl-4(5H)-oxazolylidene)methyl)benzenecarboximidamide, trifluoroacetate
      DescriptionA cell-permeable oxazolidinone-carboxamidine compound that acts as a potent, selective, and active-site targeting inhibitor of urokinase-type plasminogen activator (uPA; IC50 = 200 nM) with much reduced activity against trypsin, thrombin, tPA, and plasmin (38%, 8%, 5%, and 0% inhibition, respectively, with 100 µM UK122). Shown to effectively inhibit the migration and invasion (80% and 68% inhibition, respectively, with 100 µM UK122), but not proliferation, of uPA-expressing CFPAC-1 pancreatic cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₃N₃O₂ • CF₃CO₂H
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhu, M., et al. 2007. Mol. Cancer Ther. 6, 1348.