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1.00246

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Datasheet: 1.00246
Document Type:

Data Sheet

Product Catalog Number:

100246
Technical Data Sheet 100246 Platin/Cobalt color reference solution (Hazen 500) Certipur
Document Type:

Technical Information
COA 100246
Document Type:

Certificate of Analysis

Product Catalog Number:

100246
Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils a ...
Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content in a clinical trial and found that doxycycline selectively reduces neutrophil-derived proteases. We thus hypothesized that doxycycline acts through an effect on vascular inflammation.Sixty patients scheduled for elective open aneurysmal repair were randomly assigned to 2 weeks of low-, medium-, or high-dose doxycycline (50, 100, or 300 mg/d, respectively) or no medication (control group). Aortic wall samples were collected at the time of operation, and the effect of doxycycline treatment on vascular inflammation was evaluated. Independently of its dose, doxycycline treatment resulted in a profound but selective suppression of aortic wall inflammation as reflected by a selective 72% reduction of the aortic wall neutrophils and a 95% reduction of the aortic wall cytotoxic T-cell content (median values; Pless than 0.00003). Evaluation of major inflammatory pathways suggested that doxycycline treatment specifically quenched AP-1 and C/EBP proinflammatory transcription pathways (Pless than 0.0158, NS) and reduced vascular interleukin-6 (Pless than 0.00115), interleukin-8 (Pless than 0.00246, NS), interleukin-13 (Pless than 0.0184, NS), and granulocyte colony-stimulating factor (Pless than 0.031, NS) protein levels. Doxycycline was well tolerated; there were no adverse effects.A brief period of doxycycline treatment has a profound but selective effect on vascular inflammation and reduces aortic wall neutrophil and cytotoxic T-cell content. Results of this study are relevant for pharmaceutical stabilization of the abdominal aneurysm and possibly for other inflammatory conditions that involve neutrophils and/or cytotoxic T cells.
Document Type:

Reference

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
ADMI Color Measurement for Prove
Document Type:

Application

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
Color, ADMI as per APHA 2120 F
Document Type:

Application

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple