COA 101188
- Document Type:
- Certificate of Analysis
- Product Catalog Number:
- 101188
1.01188
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Smart Up your lab
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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More Than Sure
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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Boron in soils
- Document Type:
- Application
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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Lead in motor fuel
- Document Type:
- Application
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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Inorganics & Solvents for classical analysis
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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Certificate of Analysis 1.05404 V118804752
- Document Type:
- Certificate of Analysis
- Lot Number:
- V118804752
- Product Catalog Number:
- 1.05404
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Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type gluta ...
- Ca2+/CaM-dependent protein kinase II (CaM-KII) can phosphorylate and potentiate responses of alpha-amino3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptors in a number of systems, and recent studies implicate this mechanism in long term potentiation, a cellular model of learning and memory. In this study we have identified this CaM-KII regulatory site using deletion and site-specific mutants of glutamate receptor 1 (GluR1). Only mutations affecting Ser831 altered the 32P peptide maps of GluR1 from HEK-293 cells co-expressing an activated CaM-KII. Likewise, when CaM-KII was infused into cells expressing GluR1, the Ser831 to Ala mutant failed to show potentiation of the GluR1 current. The Ser831 site is specific to GluR1, and CaM-KII did not phosphorylate or potentiate current in cells expressing GluR2, emphasizing the importance of the GluR1 subunit in this regulatory mechanism. Because Ser831 has previously been identified as a protein kinase C phosphorylation site (Roche, K. W., O'Brien, R. J., Mammen, A. L., Bernhardt, J., and Huganir, R. L. (1996) Neuron 16, 1179-1188), this raises the possibility of synergistic interactions between CaM-KII and protein kinase C in regulating synaptic plasticity.
- Document Type:
- Reference
- Product Catalog Number:
- 04-823
- Product Catalog Name:
- Anti-phospho-GluR1 (Ser831) Antibody, clone N453, rabbit monoclonal
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Erenna SMC™ Human KIM-1 Immunoassay Kit
- Document Type:
- Protocols
- Product Catalog Number:
- 03-0118-00
- Product Catalog Name:
- SMC™ KIM-1
IMMUNOASSAY KIT