COA 101217
- Document Type:
- Certificate of Analysis
- Product Catalog Number:
- 101217
1.01217
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CHAPMAN Agar (Staphylococcus Selective Agar No. 110 acc. to CHAPMAN, 105469
- Document Type:
- Technical Information
-
More Than Sure
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Inorganics & Solvents for classical analysis
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
DEV Gelatin Agar, 110685
- Document Type:
- Technical Information
-
Smart Up your lab
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Metabolic regulation of CaMKII protein and caspases in Xenopus laevis egg extracts.
- The metabolism of the Xenopus laevis egg provides a cell survival signal. We found previously that increased carbon flux from glucose-6-phosphate (G6P) through the pentose phosphate pathway in egg extracts maintains NADPH levels and calcium/calmodulin regulated protein kinase II (CaMKII) activity to phosphorylate caspase 2 and suppress cell death pathways. Here we show that the addition of G6P to oocyte extracts inhibits the dephosphorylation/inactivation of CaMKII bound to caspase 2 by protein phosphatase 1. Thus, G6P sustains the phosphorylation of caspase 2 by CaMKII at Ser-135, preventing the induction of caspase 2-mediated apoptotic pathways. These findings expand our understanding of oocyte biology and clarify mechanisms underlying the metabolic regulation of CaMKII and apoptosis. Furthermore, these findings suggest novel approaches to disrupt the suppressive effects of the abnormal metabolism on cell death pathways.
- Document Type:
- Reference
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Anti-BFL-1 - VP2101217
- Document Type:
- Certificate of Analysis
- Lot Number:
- VP2101217
- Product Catalog Number:
- ABC339
- Product Catalog Name:
- Anti-BFL-1 Antibody
-
CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1
- Document Type:
- Reference
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Long-term pathologic consequences of acute irritant-induced asthma.
- Acute irritant-induced asthma (IrIa) or reactive airways dysfunction syndrome is caused by exposure to a high concentration of an agent. The long-term pathologic consequences of IrIa remain thus far unknown.
- Document Type:
- Reference
- Product Catalog Number:
- 17-176