COA 108543
- Document Type:
- Certificate of Analysis
- Product Catalog Number:
- 108543
1.08543
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Certificate of Analysis 1.06143 TD15008543
- Document Type:
- Certificate of Analysis
- Lot Number:
- TD15008543
- Product Catalog Number:
- 1.06143
-
Certificate of Analysis 1.06143 TD12008543
- Document Type:
- Certificate of Analysis
- Lot Number:
- TD12008543
- Product Catalog Number:
- 1.06143
-
Synthesis of light-activated antisense oligodeoxynucleotide.
- The activity of a 20-mer antisense oligodeoxynucleotide (asODN) is transiently blocked by attaching a partially complementary sense strand (sODN) via a heterobifunctional photocleavable linker (PL). The asODN-PL-sODN conjugate forms a DNA hairpin-like structure that is considerably more stable than the corresponding asODN/sODN duplex. In conjugate form, the asODN is prevented from hybridizing to exogenous RNA or DNA molecules. Activity is restored after modest exposure to UV light (lambda approximately 365 nm). Here, we provide a detailed procedure for synthesizing photoactive asODNs in good yields. Synthesis, purification and analysis of the light-activated asODN can be completed within 1-2 weeks.
- Document Type:
- Reference
- Product Catalog Number:
- 3301
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Data Sheet 1.05438.0500 / 1.05438.5000
- Document Type:
- Data Sheet
- Product Catalog Number:
- 105438
- Product Catalog Name:
- SABOURAUD 4% dextrose agar