COA 113175
- Document Type:
- Certificate of Analysis
- Product Catalog Number:
- 113175
1.13175
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User Guide (IFU) - 1.53175 - HPLC Columns
- Document Type:
- User Guide
- Product Catalog Number:
- 153175
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User Guide (IFU) - 1.53175 - Guard Cartridges
- Document Type:
- User Guide
- Product Catalog Number:
- 153175
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Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.
- Epidermal growth factor receptor (EGFR) can undergo post-translational modifications, including phosphorylation, glycosylation and ubiquitylation, leading to diverse physiological consequences and modulation of its biological activity. There is increasing evidence that methylation may parallel other post-translational modifications in the regulation of various biological processes. It is still not known, however, whether EGFR is regulated by this post-translational event. Here, we show that EGFR Arg 1175 is methylated by an arginine methyltransferase, PRMT5. Arg 1175 methylation positively modulates EGF-induced EGFR trans-autophosphorylation at Tyr 1173, which governs ERK activation. Abolishment of Arg 1175 methylation enhances EGF-stimulated ERK activation by reducing SHP1 recruitment to EGFR, resulting in augmented cell proliferation, migration and invasion of EGFR-expressing cells. Therefore, we propose a model in which the regulatory crosstalk between PRMT5-mediated Arg 1175 methylation and EGF-induced Tyr 1173 phosphorylation attenuates EGFR-mediated ERK activation.
- Document Type:
- Reference
- Product Catalog Number:
- 06-847
- Product Catalog Name:
- Anti-EGFR Antibody
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Certificate of Analysis 1.04140 13176-015
- Document Type:
- Certificate of Analysis
- Lot Number:
- 13176-015
- Product Catalog Number:
- 1.04140
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Anti-Bromodeoxyuridine, clone AH4H7-1 / 131-14871 Monoclonal Antibody
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3112654
- Product Catalog Number:
- MAB3424
- Product Catalog Name:
- Anti-BrdU Antibody, clone AH4H7-1 / 131-14871
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Anti-Bromodeoxyuridine, clone AH4H7-1 / 131-14871 Monoclonal Antibody
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2909671
- Product Catalog Number:
- MAB3424
- Product Catalog Name:
- Anti-BrdU Antibody, clone AH4H7-1 / 131-14871
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Anti-Bromodeoxyuridine, clone AH4H7-1 / 131-14871 Monoclonal Antibody
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3152184
- Product Catalog Number:
- MAB3424
- Product Catalog Name:
- Anti-BrdU Antibody, clone AH4H7-1 / 131-14871
-
Anti-Bromodeoxyuridine, clone AH4H7-1 / 131-14871 - NG1812620
- Document Type:
- Certificate of Analysis
- Lot Number:
- NG1812620
- Product Catalog Number:
- MAB3424
- Product Catalog Name:
- Anti-BrdU Antibody, clone AH4H7-1 / 131-14871
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Anti-Bromodeoxyuridine, clone AH4H7-1 / 131-14871 - NMM1701216
- Document Type:
- Certificate of Analysis
- Lot Number:
- NMM1701216
- Product Catalog Number:
- MAB3424
- Product Catalog Name:
- Anti-BrdU Antibody, clone AH4H7-1 / 131-14871