COA 113792
- Document Type:
- Certificate of Analysis
- Product Catalog Number:
- 113792
1.13792
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Fast and Precise. Thin Layer Chromatography by.
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Certificate of Analysis 1.05032 1379732
- Document Type:
- Certificate of Analysis
- Lot Number:
- 1379732
- Product Catalog Number:
- 1.05032
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Dimethyl-Histone H3 (Lys9) Peptide, biotin conjugate (residues 1-21) - 2316792
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2316792
- Product Catalog Number:
- 12-430
- Product Catalog Name:
- Dimethyl-Histone H3 (Lys9) Peptide, biotin conjugate
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Deletion of retinoic acid receptor β (RARβ) impairs pancreatic endocrine differentiation.
- All-trans retinoic acid (RA) signals via binding to retinoic acid receptors (RARs α, β, and γ). RA directly influences expression of Pdx1, a transcription factor essential for pancreatic development and beta-cell (β-cell) maturation. In this study we follow the differentiation of cultured wild-type (WT) vs. RARβ knockout (KO) embryonic stem (ES) cells into pancreatic islet cells. We found that RARβ KO ES cells show greatly reduced expression of some important endocrine markers of differentiated islet cells, such as glucagon, islet amyloid polypeptide (Iapp), and insulin 1 (Ins1) relative to WT. We conclude that RARβ activity is essential for proper differentiation of ES cells to pancreatic endocrine cells.
- Document Type:
- Reference
- Product Catalog Number:
- 06-1379