Tube label 1.16731
- Document Type:
- User Guide
- Product Catalog Number:
- 116731
1.16731
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User Guide (IFU) - 1.16731
- Document Type:
- User Guide
- Product Catalog Number:
- 116731
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Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.
- Hypopituitary Ames dwarf mice have low circulating growth hormone (GH)/IGF-I levels, and they have extended longevity and exhibit many symptoms of delayed aging. To elucidate the vascular consequences of Ames dwarfism we compared endothelial O2(-) and H2O2 production, mitochondrial reactive oxygen species (ROS) generation, expression of antioxidant enzymes, and nitric oxide (NO) production in aortas of Ames dwarf and wild-type control mice. In Ames dwarf aortas endothelial O2(-) and H2O2 production and ROS generation by mitochondria were enhanced compared with those in vessels of wild-type mice. In Ames dwarf aortas there was a less abundant expression of Mn-SOD, Cu,Zn-SOD, glutathione peroxidase (GPx)-1, and endothelial nitric oxide synthase (eNOS). NO production and acetylcholine-induced relaxation were also decreased in aortas of Ames dwarf mice. In cultured wild-type mouse aortas and in human coronary arterial endothelial cells treatment with GH and IGF significantly reduced cellular O2(-) and H2O2 production and ROS generation by mitochondria and upregulated expression of Mn-SOD, Cu,Zn-SOD, GPx-1, and eNOS. Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress.
- Document Type:
- Reference
- Product Catalog Number:
- 07-024
- Product Catalog Name:
- Anti-gp91-phox Antibody
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COA 116731
- Document Type:
- Certificate of Analysis
- Product Catalog Number:
- 116731
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Interferences spiking standard addition
- Document Type:
- Technical Information
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Analytical Quality Assurance, Standard for Hydrogen peroxide
- Document Type:
- Application
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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Interferences Dilution
- Document Type:
- Technical Information