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Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody R-PHYCOERYTHRIN* CONJUGATED, READY TO USE - 2299137
Document Type:

Certificate of Analysis
Lot Number:

2299137

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated
Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody R-PHYCOERYTHRIN* CONJUGATED, READY TO USE
Document Type:

Certificate of Analysis
Lot Number:

2967225

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated
Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody R-PHYCOERYTHRIN* CONJUGATED, READY TO USE - 2377261
Document Type:

Certificate of Analysis
Lot Number:

2377261

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated
Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody R-PHYCOERYTHRIN* CONJUGATED, READY TO USE
Document Type:

Certificate of Analysis
Lot Number:

3111538

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated
Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5.
Correct hematopoietic differentiation requires the tightly regulated execution of lineage-specific and stage-restricted gene expression programs. This process is disturbed in hematological malignancies that typically show incomplete differentiation but often also display a mixed lineage phenotype. Co-expression of lymphoid and myeloid molecules is a well-known feature of acute myeloblastic leukemia (AML) with t(8;21). These cells consistently express the B-cell-specific transcription factor PAX5, and the B-cell-specific cell surface protein CD19. However, the functional consequences of PAX5 expression are unknown. To address this question, we studied the chromatin features of CD19, which is a direct target of PAX5 in cells with and without the t(8;21) chromosomal translocation. We show that CD19 chromatin exists in a poised configuration in myeloid progenitors and that this poised chromatin structure facilitates PAX5-dependent CD19 activation. Our results also show a positive correlation between PAX5 and CD19 expression in t(8;21)-positive AML cells and demonstrate that PAX5 binds to the promoter and enhancer of CD19 gene and remodels chromatin structure at the promoter. This study shows that expression of PAX5 in leukemic cells has functional consequences and points to an important role of a progenitor-specific chromatin configuration in myeloid leukemia.
Document Type:

Reference

Product Catalog Number:

AB4227
Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody R-PHYCOERYTHRIN* CONJUGATED, READY TO USE - 2042790
Document Type:

Certificate of Analysis
Lot Number:

2042790

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated
Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody - 3291001
Document Type:

Certificate of Analysis
Lot Number:

3291001

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated
Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody - 3510852
Document Type:

Certificate of Analysis
Lot Number:

3510852

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated
Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody -2588139
Document Type:

Certificate of Analysis
Lot Number:

2588139

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated
Mouse anti HUMAN B CELLS (CD19), Monoclonal Antibody - 2562359
Document Type:

Certificate of Analysis
Lot Number:

2562359

Product Catalog Number:

MAB1794H
Product Catalog Name:

Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated