Ras-GST, agarose conjugate - 17608
- Document Type:
- Certificate of Analysis
- Lot Number:
- 17608
17-608
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Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation
- Document Type:
- Data Sheet
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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Advance your Epigenetics Research
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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Shaping Epigenetics Discovery - Epigenetics Product Selection Brochure
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.
- IL-2 is a key cytokine during proliferation and activation of T lymphocytes and functions as an auto- and paracrine growth factor. Regardless of activating effects on T lymphocytes, the absence of IL-2 has been linked to the development of autoimmune pathology in mice and humans. Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and characterized by dysregulation of lymphocyte function, transcription factor and cytokine expression, and antigen presentation. Reduced IL-2 expression is a hallmark of SLE T lymphocytes and results in decreased numbers of regulatory T lymphocytes which play an important role in preventing autoimmunity. Reduced IL-2 expression was linked to overproduction of the transcription regulatory factor cAMP-responsive element modulator (CREM)α in SLE T lymphocytes and subsequent CREMα binding to a CRE site within the IL2 promoter (-180 CRE). In this study, we demonstrate the involvement of CREMα-mediated IL2 silencing in T lymphocytes from SLE patients through a gene-wide histone deacetylase 1-directed deacetylation of histone H3K18 and DNA methyltransferase 3a-directed cytosine phosphate guanosine (CpG)-DNA hypermethylation. For the first time, we provide direct evidence that CREMα mediates silencing of the IL2 gene in SLE T cells though histone deacetylation and CpG-DNA methylation.
- Document Type:
- Reference
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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ChIPAb+ HDAC1 - DAM1764572
- Document Type:
- Certificate of Analysis
- Lot Number:
- DAM1764572
- Product Catalog Number:
- 17-608
- Product Catalog Name:
- ChIPAb+ HDAC1 - ChIP Validated Antibody and Primer Set
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ChIPAb+ HDAC1 - 1959310
- Document Type:
- Certificate of Analysis
- Lot Number:
- 1959310
- Product Catalog Number:
- 17-608
- Product Catalog Name:
- ChIPAb+ HDAC1 - ChIP Validated Antibody and Primer Set
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ChIPAb+ HDAC1 - 2016024
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2016024
- Product Catalog Number:
- 17-608
- Product Catalog Name:
- ChIPAb+ HDAC1 - ChIP Validated Antibody and Primer Set
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ChIPAb+ HDAC1 - JBC1942564
- Document Type:
- Certificate of Analysis
- Lot Number:
- JBC1942564
- Product Catalog Number:
- 17-608
- Product Catalog Name:
- ChIPAb+ HDAC1 - ChIP Validated Antibody and Primer Set
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ChIPAb+ HDAC1 - 3809766
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3809766
- Product Catalog Number:
- 17-608
- Product Catalog Name:
- ChIPAb+ HDAC1 - ChIP Validated Antibody and Primer Set