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SCC225 Sigma-AldrichYUMM 1.3 Mouse Melanoma Cell Line
The YUMM cell models recapitulate genetic drivers found in a significant proportion of human melanomas. YUMM1.3 cells retain genetic markers of the Braf/Pten mouse models, characterized by activation of Braf and inactivation of Pten and Cdkn2a, in which melanoma tumors develop with short latency.
SCC241 Sigma-AldrichYUMM5.4 Mouse Melanoma Cell Line
The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM5.4 retains WT Pten, permitting comparative analysis for parsing distinct contributions of PI3K-Akt signaling in melanoma tumorigenesis and immune evasion.
SCC232 Sigma-AldrichYUMM2.1 Mouse Melanoma Cell Line
The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM2 harbors the Braf V600E mutation and is homozygous negative for wt Pten and is Cdkn2+.
SCC226 Sigma-AldrichYUMM1.4 Mouse Melanoma Cell Line
The YUMM1.4 cell line is driven by Braf activation, Pten inactivation, and Cdkn2a inactivation. The cell line is positive for the common melanoma marker, MelanA. The cells are syngeneic with C57BL/6J mice and are very tumorigenic in vivo.
SCC234 Sigma-AldrichYUMM2.2 Mouse Melanoma Cell Line
The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM2.2 harbors a mutation that accelerates Braf/Pten-driven melanoma tumorigenesis and inactivates wt Pten and Cdkn2a.
SCC240 Sigma-AldrichYUMM5.2 Mouse Melanoma Cell Line
The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM5.2 cells are syngenic with C57BL/6 and retain markers of the Braf/Pten mouse model.
SCC224 Sigma-AldrichYUMM 1.1 Mouse Melanoma Cell Line
The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM1.1 is driven by Braf activation, Pten/Cdkn2a inactivation, and is highly tumorigenic in vivo.
SCC237 Sigma-AldrichYUMM4.1 Mouse Melanoma Cell Line
The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM4.1 is homozygous negative for Pten and Cdkn2+, and has no activating Braf mutations.
SCC235 Sigma-AldrichYUMM3.2 Mouse Melanoma Cell Line
The YUMM cell lines recapitulate genetic drivers common in human melanomas. YUMM3.2 retains WT Pten, permitting comparative analysis for parsing distinct contributions of PI3K-Akt signaling in melanoma tumorigenesis and immune evasion.
SCC236 Sigma-AldrichYUMM3.3 Mouse Melanoma Cell Line
The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM3.3 harbors the Braf V600E mutation and is homozygous negative for Cdkn2+.