Pathways and Biomarkers of Oxidative Stress
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White Paper- Modern Methods in Oxidative Stress Research
- Document Type:
- Technical Information
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RABBIT ANTI-GLUTATHIONE-S-TRANSFERASE- π [GST-π] POLYCLONAL ANTIBODY
- Document Type:
- Data Sheet
- Product Catalog Number:
- AB8902
- Product Catalog Name:
- Anti-Glutathione-S-Transferase-pi Antibody, mammalian form
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RABBIT ANTI-GLUTATHIONE-S-TRANSFERASE- π [GST-π] POLYCLONAL ANTIBODY - 2424654
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2424654
- Product Catalog Number:
- AB8902
- Product Catalog Name:
- Anti-Glutathione-S-Transferase-pi Antibody, mammalian form
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RABBIT ANTI-GLUTATHIONE-S-TRANSFERASE- π [GST-π] - 3907843
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3907843
- Product Catalog Number:
- AB8902
- Product Catalog Name:
- Anti-Glutathione-S-Transferase-pi Antibody, mammalian form
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RABBIT ANTI-GLUTATHIONE-S-TRANSFERASE- π [GST-π] POLYCLONAL ANTIBODY
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3011578
- Product Catalog Number:
- AB8902
- Product Catalog Name:
- Anti-Glutathione-S-Transferase-pi Antibody, mammalian form
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Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.
- Cerebral cavernous malformations 2 (CCM2) loss is associated with the familial form of CCM disease. The protein kinase MEKK3 (MAP3K3) is essential for embryonic angiogenesis in mice and interacts physically with CCM2, but how this interaction is mediated and its relevance to cerebral vasculature are unknown. Here we report that Mekk3 plays an intrinsic role in embryonic vascular development. Inducible endothelial Mekk3 knockout in neonatal mice is lethal due to multiple intracranial haemorrhages and brain blood vessels leakage. We discover direct interaction between CCM2 harmonin homology domain (HHD) and the N terminus of MEKK3, and determine a 2.35 Å cocrystal structure. We find Mekk3 deficiency impairs neurovascular integrity, which is partially dependent on Rho-ROCK signalling, and that disruption of MEKK3:CCM2 interaction leads to similar neurovascular leakage. We conclude that CCM2:MEKK3-mediated regulation of Rho signalling is required for maintenance of neurovascular integrity, unravelling a mechanism by which CCM2 loss leads to disease.
- Document Type:
- Reference
- Product Catalog Number:
- AB8902
- Product Catalog Name:
- Anti-Glutathione-S-Transferase-pi Antibody, mammalian form
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Anti-Glutathione-S-Transferase-pi Antibody, mammalian form (India)
- Document Type:
- SDS
- Product Catalog Number:
- AB8902
- Product Catalog Name:
- Anti-Glutathione-S-Transferase-pi Antibody, mammalian form
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Anti-Glutathione-S-Transferase-pi Antibody, mammalian form (Cyprus)
- Document Type:
- SDS
- Product Catalog Number:
- AB8902
- Product Catalog Name:
- Anti-Glutathione-S-Transferase-pi Antibody, mammalian form
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Anti-Glutathione-S-Transferase-pi Antibody, mammalian form (South Africa)
- Document Type:
- SDS
- Product Catalog Number:
- AB8902
- Product Catalog Name:
- Anti-Glutathione-S-Transferase-pi Antibody, mammalian form