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Cobalt chloride decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells.
It is known that cells suffer a chronic hypoxic condition during the development of proximal tubulointerstitial disease. However, it is accepted that extracellular-superoxide dismutase (EC-SOD) protects the cells from oxidative stress. The purpose of this study was to elucidate the regulation of EC-SOD expression in cells under hypoxia. The results show that the expressions of EC-SOD mRNA and protein in cobalt chloride (CoCl(2))-treated COS7 cells decreased in a dose- and time-dependent manner, whereas the expressions of other SOD isoforms (Cu/Zn-SOD and Mn-SOD) were not changed. The down-regulation of EC-SOD mRNA was suppressed by pre-treatment with the antioxidant trolox and the p38 mitogen-activated protein kinase (p38-MAPK) inhibitor SB203580. It is concluded that the expression of EC-SOD is decreased through ROS and p38-MAPK signalling cascades and that the down-regulation of EC-SOD leads to a decrease in the resistance to oxidative stress of COS7 cells under hypoxia induced by CoCl(2).
Document Type:

Reference

Product Catalog Number:

CT01
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MTT Cell Growth Assay Kit
Chloride in building materials
Document Type:

Application

Product Catalog Number:

Multiple
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Multiple
Chloride Determination for COD Cell Tests for Seawater
Document Type:

Application

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
Tin(II) chloride dihydrate EMPROVE® ESSENTIAL Ph Eur,BP,JPE
Document Type:

Operational Excellence Dossier

Product Catalog Number:

107813
Product Catalog Name:

Tin(II) chloride dihydrate
Chloride in concrete
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Application

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
Chloride, not sodium, stimulates expression of the {gamma} subunit of Na/K-ATPase and activates JNK in response to hypertonicity in mouse IMCD3 cells
Document Type:

Reference

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
Chloride in red and white wines
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Application

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Multiple
Product Catalog Name:

Multiple
Chloride in pickled cabbage
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Application

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Multiple
Product Catalog Name:

Multiple
Sodium Chloride Increases Aβ Levels by Suppressing Aβ Clearance in Cultured Cells.
Recent studies suggest that high-salt diet is associated with cognitive decline in human and mouse. The fact that genetic factors account for less than 50% cases of sporadic Alzheimer's disease (AD) highlights the important contribution of environmental factors, such as high-salt diet, in AD pathogenesis. However, whether and how high-salt diet fits the "amyloid cascade" hypothesis remains unexplored. Here, we show sodium chloride (NaCl) could increase Aβ levels in the medium of HEK293 cells overexpressing amyloid precursor protein (APP) or C99 fragment. NaCl treatment dose not affect APP level, gamma secretase level or activity. Instead, NaCl treatment suppresses the capacity of cells to clear Aβ and reduces Apolipoprotein E (ApoE) level. Finally, NaCl treated THP-1 or BV2 cells are inefficient in clearing Aβ when co-cultured with rat primary neurons. Our study suggests that high-salt diet may increase AD risk by directly modulating Aβ levels.
Document Type:

Reference

Product Catalog Number:

MAB5232
Tin(II) chloride dihydrate EMPROVE® ESSENTIAL Ph Eur,BP,JPE
Document Type:

Quality Management Dossier

Product Catalog Number:

107813
Product Catalog Name:

Tin(II) chloride dihydrate

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Cobalt chloride decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells.

Chloride in building materials

Chloride Determination for COD Cell Tests for Seawater

Tin(II) chloride dihydrate EMPROVE® ESSENTIAL Ph Eur,BP,JPE

Chloride in concrete

Chloride, not sodium, stimulates expression of the {gamma} subunit of Na/K-ATPase and activates JNK in response to hypertonicity in mouse IMCD3 cells

Chloride in red and white wines

Chloride in pickled cabbage

Sodium Chloride Increases Aβ Levels by Suppressing Aβ Clearance in Cultured Cells.

Tin(II) chloride dihydrate EMPROVE® ESSENTIAL Ph Eur,BP,JPE

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