Immobilon Transfer Membranes: For superior protein and nucleic acid blots
- Document Type:
- Data Sheet
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
ipvh00010mm
37 Results
Advanced Search
Showing
Narrow Your Results Use the filters below to refine your search
Document Type
-
-
SNAP i.d. 2.0 System Brochure
- Document Type:
- Brochure
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion.
- Irreversible EGFR inhibitors can circumvent acquired resistance to first-generation reversible, ATP-competitive inhibitors in the treatment of non-small-cell lung cancer. They contain both a driver group, which assures target recognition, and a warhead, generally an acrylamide or propargylamide fragment that binds covalently to Cys797 within the kinase domain of EGFR. We performed a systematic exploration of the role for the warhead group, introducing different cysteine-trapping fragments at position 6 of a traditional 4-anilinoquinazoline scaffold. We found that different reactive groups, including epoxyamides (compounds 3-6) and phenoxyacetamides (compounds 7-9), were able to irreversibly inhibit EGFR. In particular, at significant lower concentrations than gefitinib (1), (2R,3R)-N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(piperidin-1-ylmethyl)oxirane-2-carboxamide (6) inhibited EGFR autophosphorylation and downstream signaling pathways, suppressed proliferation, and induced apoptosis in gefitinib-resistant NSCLC H1975 cells, harboring the T790M mutation in EGFR.
- Document Type:
- Reference
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Re-Blot Plus Western Blot Recycling Kit
- Document Type:
- User Guide
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
ReBlot Plus Western Blot Recycling Visual Guide
- Document Type:
- Protocols
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling.
- Obesity and hyperlipidaemia are associated with insulin resistance (IR); however, the mechanisms responsible remain incompletely understood. Pro-atherogenic hyperlipidaemic states are characterized by inflammation, oxidant stress, and pathophysiologic oxidized lipids, including ligands for the scavenger receptor CD36. Here we tested the hypothesis that the absence of CD36 protects mice from IR associated with diet-induced obesity and hyperlipidaemia.
- Document Type:
- Reference
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Immobilon -P Blotting Sandwiches
- Document Type:
- User Guide
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Immobilon®-P Transfer Membrane User Guide
- Document Type:
- User Guide
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
User Guide - Immobilon®P Transfer Membrane
- Document Type:
- User Guide
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
-
Antibody recovery and reuse in the SNAP i.d.®2.0 immunodetection system
- Document Type:
- Technical Information