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  • Anti-TM7SF2 -2702105

    Document Type:
    Certificate of Analysis
    Lot Number:
    2702105
    Product Catalog Number:
    06-1026

  • Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery. 23414781

    Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery, endogenous nuclear envelope proteins that control such a mechanism in mammalian cells have yet to be widely identified.To search for such proteins, 23 nuclear envelope transmembrane proteins were screened for their ability to promote peripheral localization of human chromosomes in HT1080 fibroblasts. Five of these proteins had strong effects on chromosome 5, but individual proteins affected different subsets of chromosomes. The repositioning effects were reversible and the proteins with effects all exhibited highly tissue-restricted patterns of expression. Depletion of two nuclear envelope transmembrane proteins that were preferentially expressed in liver each reduced the normal peripheral positioning of chromosome 5 in liver cells.The discovery of nuclear envelope transmembrane proteins that can modulate chromosome position and have restricted patterns of expression may enable dissection of the functional relevance of tissue-specific patterns of radial chromosome positioning.
    Document Type:
    Reference
    Product Catalog Number:
    Multiple
    Product Catalog Name:
    Multiple

  • Certificate of Analysis 620 1026

    Document Type:
    Certificate of Analysis
    Lot Number:
    1026
    Product Catalog Number:
    620
    Product Catalog Name:
    Giemsa Stain Solution Modified Azure Blend

  • Certificate of Analysis 620G 1026

    Document Type:
    Certificate of Analysis
    Lot Number:
    1026
    Product Catalog Number:
    620G
    Product Catalog Name:
    Giemsa Stain Solution Original Azure Blend