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  • The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport 29768176

    Unc-93 homolog B1 (UNC93B1) is a key regulator of nucleic acid (NA)-sensing Toll-like receptors (TLRs). Loss of NA-sensing TLR responses in UNC93B1-deficient patients facilitates Herpes simplex virus type 1 (HSV-1) encephalitis. UNC93B1 is thought to guide NA-sensing TLRs from the endoplasmic reticulum (ER) to their respective endosomal signaling compartments and to guide the flagellin receptor TLR5 to the cell surface, raising the question of how UNC93B1 mediates differential TLR trafficking. Here, we report that UNC93B1 regulates a step upstream of the differential TLR trafficking process. We discovered that UNC93B1 deficiency resulted in near-complete loss of TLR3 and TLR7 proteins in primary splenic mouse dendritic cells and macrophages, showing that UNC93B1 is critical for maintaining TLR expression. Notably, expression of an ER-retained UNC93B1 version was sufficient to stabilize TLRs and largely restore endosomal TLR trafficking and activity. These data are critical for an understanding of how UNC93B1 can regulate the function of a broad subset of TLRs.
    Document Type:
    Reference
    Product Catalog Number:
    Multiple
    Product Catalog Name:
    Multiple

  • Anti-TLR3, clone PaT3 - Q3509827

    Document Type:
    Certificate of Analysis
    Lot Number:
    Q3509827
    Product Catalog Number:
    MABF2205-100UG
    Product Catalog Name:
    Anti-TLR3 Antibody, clone PaT3

  • Anti-RNF4, clone 11-3.1 - Q4177682

    Document Type:
    Certificate of Analysis
    Lot Number:
    Q4177682
    Product Catalog Number:
    MABE2005-100UG
    Product Catalog Name:
    Anti-RNF4 Antibody, clone 11-3.1
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