524624
Phosphatase Inhibitor Cocktail I
liquid, for the inhibition of alkaline phosphatases and serine/threonine protein phosphatases
別名:
Phosphatase inhibitor
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この商品について
UNSPSC Code:
12352200
NACRES:
NA.28
Form:
liquid
Solubility:
water: soluble
Storage temp.:
−20°C
製品名
Phosphatase Inhibitor Cocktail Set I, Phosphatase Inhibitor Cocktail Set I contains three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A.
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: soluble
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
Alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A
Alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A
Product does not compete with ATP.
Reversible: no
General description
A cocktail of three inhibitors that will inhibit alkaline phosphatases as well as serine/threonine protein phosphatases such as PP1 and PP2A. This product is provided as a set of five 1 ml vials. Each vial contains 1 ml phosphatase inhibitor cocktail solubilized in DMSO with the following components: Bromotetramisole oxalate (2.5 mM), Cantharidin (Cat. No. 210155; 500 µM), and Microcystin-LR (Cat. No. 475815; 500 nM).
Legal Information
Not available for sale outside of the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Physical form
In DMSO.
Preparation Note
For long-term storage, aliquot and freeze (-20°C). Dilute 1:100 just prior to use.
保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Rama K Mishra et al.
Chemical biology & drug design, 94(4), 1813-1823 (2019-07-02)
Mnk kinases (Mnk1 and 2) are downstream effectors of Map kinase pathways and regulate phosphorylation of eukaryotic initiation factor 4E. Engagement of the Mnk pathway is critical in acute myeloid leukemia (AML) leukemogenesis and Mnk inhibitors have potent antileukemic properties
An Phu Tran Nguyen et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(29), 17296-17307 (2020-07-08)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of late-onset, autosomal-dominant familial Parkinson's disease (PD). LRRK2 functions as both a kinase and GTPase, and PD-linked mutations are known to influence both enzymatic activities. While PD-linked LRRK2
Agnes S Zybura et al.
The Journal of biological chemistry, 295(33), 11845-11865 (2020-07-03)
Nav1.6 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critical for initiation and propagation of neuronal impulses. Thus, Nav1.6 modulation and dysfunction may have profound effects on input-output properties of neurons
Hajime Maeda et al.
Respiratory research, 23(1), 340-340 (2022-12-11)
Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization. We and others have shown that hyperoxia causes senescence in cultured lung epithelial cells and fibroblasts.
David Shechter et al.
Nature protocols, 2(6), 1445-1457 (2007-06-05)
Histone proteins are the major protein components of chromatin, the physiologically relevant form of the genome (or epigenome) in all eukaryotic cells. Chromatin is the substrate of many biological processes, such as gene regulation and transcription, replication, mitosis and apoptosis.
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 524624-1SETCN | 04055977197471 |
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