901531
Pomalidomide-PEG3-Alkyne
≥95%
別名:
N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanamide, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
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この商品について
ligand
pomalidomide
Quality Segment
assay
≥95%
form
powder or crystals
reaction suitability
reaction type: click chemistry, reagent type: ligand-linker conjugate
functional group
alkyne
storage temp.
2-8°C
SMILES string
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCOCCOCCOCC#C)=O)=O)NC1=O
InChI
1S/C23H25N3O8/c1-2-9-32-11-13-34-14-12-33-10-8-19(28)24-16-5-3-4-15-20(16)23(31)26(22(15)30)17-6-7-18(27)25-21(17)29/h1,3-5,17H,6-14H2,(H,24,28)(H,25,27,29)
InChI key
CWEPVHMTILTQIG-UHFFFAOYSA-N
Application
Protein degrader builiding block Pomalidomide-PEG3-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
Other Notes
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to ProteinDegradation
Targeted Protein Degradation: from ChemicalBiology to Drug Discovery
Impact of linker length on the activity of PROTACs
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to ProteinDegradation
Targeted Protein Degradation: from ChemicalBiology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
wgk
WGK 3
保管分類
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable