930458
OxMet2-alkyne
別名:
(3-Phenyl-1,2-oxaziridin-2-yl)(4-(prop-2-yn-1-yloxy)piperidin-1-yl)methanone
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
description
Application: Chemoproteomics
Quality Level
form
liquid
storage temp.
−20°C
SMILES string
O=C(N1OC1C2=CC=CC=C2)N(CC3)CCC3OCC#C
InChI key
ZAZCIGLVVPPSLS-UHFFFAOYSA-N
Application
OxMet2-alkyne is an oxaziridine probe that can be used to label methionines. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications (Zanon et al. 2021). The method uses light or heavy labelling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016)
Other Notes
Profiling the proteome-wide selectivity of diverse electrophiles
A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes
Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells
A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs
Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile
Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity
A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes
Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells
A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs
Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile
Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity
保管分類
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
930458-VAR: + 930458-BULK: + 930458-50MG:
jan
Profiling the proteome-wide selectivity of diverse electrophiles
Patrick R. A. Zanon, Fengchao Yu, et al
ChemRxiv : the preprint server for chemistry (2021)
A H El-Khatib et al.
Journal of mass spectrometry : JMS, 52(8), 543-549 (2017-06-04)
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) derivatives are applied in quantitative proteomics owing to their ability to react with different functional groups, to harbor lanthanoides and hence their compatibility with molecular and elemental mass spectrometry. The new DOTA derivatives, namely Ln-MeCAT-Click and Ln-DOTA-Dimedone
Zarko V Boskovic et al.
ACS chemical biology, 11(7), 1844-1851 (2016-04-12)
Unbiased binding assays involving small-molecule microarrays were used to identify compounds that display unique patterns of selectivity among members of the zinc-dependent histone deacetylase family of enzymes. A novel, hydroxyquinoline-containing compound, BRD4354, was shown to preferentially inhibit activity of HDAC5