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Merck

07-013

Anti-MeCP2 Antibody

Upstate®, from rabbit

別名:

MeCP-2 protein, mental retardation, X-linked 16, mental retardation, X-linked 79, methyl CpG binding protein 2, methyl CpG binding protein 2 (Rett syndrome)

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
112

主要文書

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Quality Level

100

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, mouse

packaging

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NP_004983

UniProt accession no.

P51608

shipped in

ambient

target post-translational modification

unmodified

Gene Information

mouse ... Mecp2(17257)
rat ... Mecp2(29386)

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関連するカテゴリー

General description

NA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, imprinting, and X chromosome inactivation. Methyl CpG binding proteins (MeCPs) specifically recognize methylated regions of DNA and repress transcription both directly and by association with known corepressor proteins which include members of the histone deacetylase protein families.
~75 kDa observed

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 465-478 of mouse MeCP2 (C-PRPNREEPVDSRTP) with an N-terminal cysteine added for conjugation purposes.

Application

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histones
Use Anti-MeCP2 Antibody (rabbit polyclonal antibody) validated in WB to detect MeCP2 also known as MeCP-2 protein, mental retardation X-linked 16, mental retardation X-linked 79, methyl CpG binding protein 2.

Biochem/physiol Actions

Predicted to cross-react with human based on the conservation of the immunogenic sequence.
Recognizes MeCP2, Mr 75 kDa. A protein at ~75 kDa was also observed in HeLa nuclear extract. This protein was competed by pre-incubation of the antibody with the immunogenic peptide, suggesting that some HeLa strains contain MeCP2 or a related protein, contrary to a previous report.

Physical form

Purified rabbit polyclonal IgG in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide.
Format: Purified
Protein A purified

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse Brain lysate.
Evaluated by Western Blot on Mouse Brain lysates.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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試験成績書（COA）

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Marie Anaïs Labouesse et al.
Epigenetics, 10(12), 1143-1155 (2015-11-18)
Maternal infection during pregnancy increases the risk of neurodevelopmental disorders in the offspring. In addition to its influence on other neuronal systems, this early-life environmental adversity has been shown to negatively affect cortical γ-aminobutyric acid (GABA) functions in adult life
A WW domain binding region in methyl-CpG-binding protein MeCP2: impact on Rett syndrome.
Jan P Buschdorf, Wolf H Stratling
Journal of Molecular Medicine null
An Obligate Role for Membrane-associated Neutral Sphingomyelinase Activity in Orienting Chemotactic Migration of Human Neutrophils.
Sitrin RG, Sassanella TM, Petty HR
American Journal of Respiratory Cell and Molecular Biology null
Yuki Yagasaki et al.
PloS one, 13(5), e0198268-e0198268 (2018-05-31)
Loss or gain of copy number of the gene encoding the transcription factor methyl-CpG-binding protein 2 (MeCP2) leads to neurodevelopmental disorders (Rett and MeCP2 duplication syndrome), indicating that precisely regulated MeCP2 expression during development is critical for mental health. Consistent
Ocular MECP2 protein expression in patients with and without Rett syndrome.
Jain D, Singh K, Chirumamilla S, Bibat GM, Blue ME, Naidu SR, Eberhart CG
Pediatric Neurology null
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関連コンテンツ

Shaping Epigenetics Discovery - Epigenetics Product Selection Brochure

"Epigenetics describes heritable changes in gene expression caused by non-genetic mechanisms instead of by alterations in DNA sequence. These changes can be cell- or tissue-specific, and can be passed on to multiple generations. Epigenetic regulation enriches DNAbased information, allowing a cell to vary its response across diverse biological and environmental contexts. Although epigenetic mechanisms are primarily centered in the nucleus, these mechanisms can be induced by environmental signals such as hormones, nutrients, stress, and cellular damage, pointing to the involvement of cytoplasmic and extracellular factors in epigenetic regulation."

Product Selection Guide - Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.

Signaling Product Guide: Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.

グローバルトレードアイテム番号

カタログ番号GTIN
07-01304053252585944
07-013-25UG04054839342479

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