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1.37112

Poloxamer 188

EMPROVE® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., ChP, NF

別名:

Polyethylene glycol, propoxylated

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この商品について

化学式:
(C3H6O · C2H4O)x
CAS番号:
9003-11-6
UNSPSC Code:
12352112
MDL number:
MFCD00082049
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Quality Level

500

agency

ChP, NF, Ph. Eur.

product line

EMPROVE® EXPERT

form

solid

technique(s)

API processing | nano-milling: suitable

pH

5-7.5 (20 °C, 10 g/L in H2O)

mp

52 °C

transition temp

flash point 260 °C

density

1.06 g/cm3 at 25 °C

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation
solubility enhancement

storage temp.

2-25°C

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Poloxamer 188 is used as surfactant in a variety of liquid formulations and acts e.g. as emulsifying, solubilizing and wetting agent.
Due to its low microbial and endotoxin limits, Poloxamer 188 Emprove® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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保管分類

11 - Combustible Solids

wgk

WGK 1

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資料

Use of Stabilizers and Surfactants to Prevent Protein Aggregation

This article outlines critical factors in long-term stability of proteins, and how different stabilizers protect again mechanical and thermal stress.

Improving API Solubility using API Processing

Instead of addressing API solubility during formulation, tackle it early during development. Read about the various methods for API processing.

関連コンテンツ

グローバルトレードアイテム番号

カタログ番号GTIN
1.37112.000104054839338472
1.37112.901004054839338496
1.37112.100004054839338489
1.37112.902504054839338502