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Merck

1.00895

スクラロース

granular, EMPROVE® ESSENTIAL, Ph. Eur., ChP, JPE, NF

別名:

1,6-ジクロロ-1,6-ジデオキシ-β-D-フルクトフラノシル-4-クロロ-4-デオキシ-α-D-ガラクトピラノシド, E955, トリクロロスクロース

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この商品について

実験式（ヒル表記法）:
C12H19Cl3O8
CAS番号:
56038-13-2
分子量:
397.63
EC Index Number:
259-952-2
UNSPSC Code:
12352121
Beilstein/REAXYS Number:
3654410
MDL number:
MFCD03648615

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SMILES string

OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl

InChI key

BAQAVOSOZGMPRM-QBMZZYIRSA-N

InChI

1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1

agency

ChP, JPE, NF, Ph. Eur.

product line

EMPROVE® ESSENTIAL

form

fine powder, granular

particle size

≥80 μm (d90)

pH

6-8 (20 °C, 100 g/L in H2O)

mp

130 °C (decomposition)

density

1.62 g/cm3 at 20 °C

application(s)

liquid formulation
pharmaceutical
solid formulation

storage temp.

15-25°C

Quality Level

500

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関連するカテゴリー

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sucralose is a high-intensity sweetener which is non-cariogenic and suitable for diabetics and patients with an impaired glucose tolerance. In addition, it is readily soluble and masks both bitterness and medicinal off-notes with equal ease – making it exceptionally well-suited for pharmaceutical applications.
Our Sucralose is available in micronized or granular form, both pharmaceutical grade, allowing you to choose depending on your individual needs. Due to its optimal dispersion behavior, sucralose powder is typically recommended for solid dose formulations, while the fast dissolution behavior of sucralose granular makes it very well-suited for liquid formulations.

Biochem/physiol Actions

人工甘味料です。舌で味を感知することができます。腸内分泌細胞上で甘味受容体T1R2/T1R3を活性化させ、グルカゴン様ペプチド-1およびグルコース依存性インスリン分泌ペプチドの分泌を促します。

Features and Benefits

  • Excellent sugar-like taste profiles
  • Masking bitter aftertaste and medical off-notes with ease
  • High sweetness potency offers improved cost-efficiency
  • Enhanced stability
  • Non-cariogenic and suitable for diabetics and patients with phenylketonuria

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The substance 1.00895 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

保管分類

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

試験成績書（COA）

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資料

Strategies for the Development of Safe and Effective Pediatric Formulations

Medicine for children poses unique formulation challenges compared to adults. Consider developmental physiology and age specifics when designing pharmaceuticals. Quality issues can severely impact patient safety. Therefore, excipient quality, supplier selection, and supply chain security are crucial, particularly for pediatric formulations.

関連コンテンツ

Pediatric Formulations

Developing formulations specifically for infants and children is increasingly important. To help you master these challenges effectively, we offer an extensive portfolio of well-established high-quality excipients and APIs for pediatric pharmaceutical formulations that are proven in practice.

Taste Optimization in Solid Dose: A Human Sensory Panel Study

グローバルトレードアイテム番号

カタログ番号GTIN
1.00895.901004027269161439
1.00895.001004027269161392
1.00895.100004027269161415

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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