13-107
Core Histones
Highly pure core histones proteins (H2A, H2B, H3 and H4) including H1 purified from chicken erythrocytes, suitable as a substrate for histone modification assays (HAT, HDAC, DNMT) and nucleosome assembly studies.
別名:
Core Histone Proteins
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この商品について
UNSPSC Code:
12352200
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
chicken
biological source
chicken
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (histone acetyltransferase (HAT))
shipped in
dry ice
General description
Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin. Some histones function as spools for the thread-like DNA to wrap around forming a nucleosome. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional H1 histone proteins are associated with each nucleosome to maintain the chromosome structure.
Application
Core histones and histone H1, purified from chicken erythrocytes; suitable as a substrate for HAT assays; purity = 90%
Physical form
Lyophilized
Preparation Note
Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -70°C
Analysis Note
rountinely evaluated by immunoblot using Anti-Histone H3 (05-499) and Anti-Histone H4 (07-108)
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
13-107:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Human erythropoietin-specific sites of monoclonal antibody-mediated neutralization.
M R Fibi,M Aslan,P Hintz-Obertreis,J U Pauly,M Gerken,G Luben,L Lauffer,B Siebold,W Stuber,G Nau
Blood null
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia.
D E Pellegrini-Giampietro,A Cozzi,F Peruginelli,P Leonardi,E Meli,R Pellicciari,F Moroni
The European Journal of Neuroscience null
Analysis of nuclear receptor acetylation.
Chenguang Wang,Michael Powell,Lifeng Tian,Richard G Pestell
Methods in Molecular Biology null
AtFKBP53 is a histone chaperone required for repression of ribosomal RNA gene expression in Arabidopsis.
Hong Li,Sheng Luan
Cell research null
Christina Schellenbacher et al.
Journal of virology, 83(19), 10085-10095 (2009-07-31)
The amino (N) terminus of the human papillomavirus (HPV) minor capsid protein L2 can induce low-titer, cross-neutralizing antibodies. The aim of this study was to improve immunogenicity of L2 peptides by surface display on highly ordered, self-assembled virus-like particles (VLP)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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