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219557

Cerulenin

Name: Cerulenin
Brand: MM

from Cephalosporium caerulens, ≥98% (TLC), solid, de novo phospholipid synthesis inhibito, Calbiochem

別名:

Cerulenin, Cephalosporium caerulens

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この商品について

実験式（ヒル表記法）:

C₁₂H₁₇NO₃

CAS番号:

17397-89-6

分子量:

223.27

UNSPSC Code:

41106500

NACRES:

NA.77

MDL number:

MFCD00083595

Assay:

≥98% (TLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

製品名

Cerulenin, Cephalosporium caerulens, An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.

Quality Segment

100

description

Merck USA index - 14, 2004

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to off-white

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL, acetone: soluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

NC(=O)[C@@H]1O[C@@H]1C(=O)CC\C=C\C\C=C\C

InChI

1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1

InChI key

GVEZIHKRYBHEFX-NQQPLRFYSA-N

詳細

General description

An anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.

Biochem/physiol Actions

Primary Target
sterol & fatty acid biosynthesis

Packaging

Packaged under inert gas

Other Notes

Loftus, T.M., et al. 2000. Science288, 2379.
Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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ピクトグラム

GHS07

注意喚起語

Warning

ハザードコード

H302

注意事項

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 3

引火点 (F)

Not applicable

引火点（°C）