265005
Dexamethasone
≥99% (TLC), solid, NOS induction inhibitor, Calbiochem
別名:
Dexamethasone, 9α-Fluoro-16α-methylprednisolone
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この商品について
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze
製品名
Dexamethasone, Most active and highly stable glucocorticoid.
description
Merck USA index - 14, 2943
Quality Segment
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 25 mg/mL, chloroform: soluble, ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
F[C@@]21[C@H]([C@H]4[C@@]([C@@]([C@@H](C4)C)(O)C(=O)CO)(C[C@@H]2O)C)CCC3=CC(=O)C=C[C@@]31C
InChI
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key
UREBDLICKHMUKA-CXSFZGCWSA-N
General description
Most active and highly stable glucocorticoid. Causes a reduction in cyclin A and Cdk2 activity, and inhibition of G1/S transition in osteoblasts. Inhibits the phosphorylation of retinoblastoma (Rb) protein. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+ - K+ pump. Induces apoptosis in human thymocytes.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Phosphorylation of rb protein
Phosphorylation of rb protein
Product does not compete with ATP.
Reversible: no
Target IC50: 5 nM Inhibiting the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Reil, T.D., et al. 2000. J. Surg. Res.92, 108.
Smith, E., et al. 2000. J.Biol. Chem. 275, 1992.
Petit, P.X., et al. 1995. J. Cell Biol.130, 157.
Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
Donis, J.A., et al. 1993. Biotechniques15, 786.
Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916.
Sarin, A., et al. 1993. J. Exp. Med.178, 1693.
Vandewalle, A., et al. 1993. J. Cell Physiol.156, 383.
Nieto, M.A., et al. 1992. Clin. Exp. Immunol.88, 341.
Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
Warters, R.L. 1992. Cancer Res.52, 883.
Sperber, K., et al. 1991. J. Allergy Clin. Immunol.87, 490.
Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA78, 5588.
Smith, E., et al. 2000. J.Biol. Chem. 275, 1992.
Petit, P.X., et al. 1995. J. Cell Biol.130, 157.
Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
Donis, J.A., et al. 1993. Biotechniques15, 786.
Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916.
Sarin, A., et al. 1993. J. Exp. Med.178, 1693.
Vandewalle, A., et al. 1993. J. Cell Physiol.156, 383.
Nieto, M.A., et al. 1992. Clin. Exp. Immunol.88, 341.
Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
Warters, R.L. 1992. Cancer Res.52, 883.
Sperber, K., et al. 1991. J. Allergy Clin. Immunol.87, 490.
Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA78, 5588.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
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注意喚起語
Danger
ハザードコード
Hazard Classifications
Repr. 1B
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable