287815
3,4-Dichloroisocoumarin
別名:
3,4-Dichloroisocoumarin
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この商品について
実験式（ヒル表記法）:
C9H4Cl2O2
CAS番号:
分子量:
215.03
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (elemental analysis)
Form:
lyophilized solid
Storage condition:
OK to freeze, desiccated
assay
≥99% (elemental analysis)
Quality Segment
form
lyophilized solid
potency
5-100 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white
solubility
DMF: 10 mM, DMSO: 10 mM
shipped in
ambient
storage temp.
2-8°C
SMILES string
Clc1[o][c](c2c(c1Cl)cccc2)=O
InChI
1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
InChI key
SUGXUUGGLDCZKB-UHFFFAOYSA-N
General description
A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 µM.
A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.
Effective concentration: 5-100 µM; t½ = 20 min at pH 7.5.
Biochem/physiol Actions
Cell permeable: no
Primary Target
serine proteases
serine proteases
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Cain, K., et al. 1994. Biochem. Cell Biol.72, 631.
Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
Odake, S., et al. 1991. Biochemistry 30, 2217.
Harper, J.W., et al. 1985. Biochemistry24, 1831.
Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
Odake, S., et al. 1991. Biochemistry 30, 2217.
Harper, J.W., et al. 1985. Biochemistry24, 1831.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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注意喚起語
Danger
ハザードコード
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標的臓器
Respiratory system
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
一体何が起きているの？
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable