317240
Metformin
≥97% (titration), solid, AMPK signaling activator, Calbiochem®
別名:
Metformin, 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
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この商品について
実験式（ヒル表記法）:
C4H11N5 · xHCl
CAS番号:
分子量:
129.16 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (titration)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
製品名
Metformin, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.
Quality Segment
description
Merck USA index - 14, 5938
assay
≥97% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
Cl.N(C)(C)C(=N\C(=N\[H])\N)N
InChI
1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChI key
OETHQSJEHLVLGH-UHFFFAOYSA-N
General description
An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
Biochem/physiol Actions
Cell permeable: no
Primary Target
AMP-activated protein kinase (AMPK)
AMP-activated protein kinase (AMPK)
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
注意喚起語
Warning
ハザードコード
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
保管分類
11 - Combustible Solids
WGK
WGK 1
引火点 (F)
Not applicable
引火点（°C）
Not applicable