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344845

Fumagillin, Aspergillus fumigatus

Name: Fumagillin, <i>Aspergillus fumigatus</i>
Brand: MM

Antiprotozoal agent and angiogenesis inhibitor.

別名:

Fumagillin, Aspergillus fumigatus

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この商品について

実験式（ヒル表記法）:

C₂₆H₃₄O₇

CAS番号:

23110-15-8

分子量:

458.54

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD03990453

Assay:

≥90% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

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特性

Quality Segment

100

description

Merck USA index - 14, 4286

assay

≥90% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to off-white

solubility

methanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

O1[C@@](C1CC=C(C)C)([C@@H]2[C@]3(OC3)CC[C@H]([C@H]2OC)OC(=O)\C=C\C=C\C=C\C=C\C(=O)O)C

InChI

1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20?,23-,24-,25+,26+/m1/s1

InChI key

NGGMYCMLYOUNGM-IJIYPQOHSA-N

詳細

General description

An inhibitor of angiogenesis. Has selective cytostatic effects against ras transformed cells (IC₅₀ = 10 pM). Antiprotozoal agent active against sporozoan parasites in bees and myxozoan parasites in fish.

Antiprotozoal agent and angiogenesis inhibitor. Acts as an inhibitor of methionine amino-peptidase 2.

Biochem/physiol Actions

Primary Target
Methionine amino-peptidase 2

Product does not compete with ATP.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Zhang, P., et al. 2002. J. Biomed. Sci.9, 34.
Stepien, H., et al. 1996. J. Endocrinol.150, 99.
Abrams, J.S., et al. 1994. Cancer74, 1164.
Jenkins, D.C., et al. 1993. Br. J. Cancer68, 856.
Le Querrec, A., et al. 1993. Baillieres Clin. Hematol.6, 711.
Molnar, K. 1993. Acta Vet. Hung. 41, 51.
Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
Brackett, J.M., et al. 1988. J. Agric. Food Chem.36, 762.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c