400046
Hydroxyurea
≥98% (HPLC), solid, RNR inhibitor, Calbiochem
別名:
Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I
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この商品について
実験式（ヒル表記法）:
CH4N2O2
CAS番号:
分子量:
76.05
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
eCl@ss:
32160702
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze
製品名
Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.
Quality Segment
description
Merck USA index - 14, 4848
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N(O)C(=O)N
InChI
1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key
VSNHCAURESNICA-UHFFFAOYSA-N
General description
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
Other Notes
Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
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ハザードコード
注意喚起語
Danger
Hazard Classifications
Muta. 1B - Repr. 2
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable