400046
Hydroxyurea
≥98% (HPLC), solid, RNR inhibitor, Calbiochem
別名:
Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I
製品名
Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.
SMILES string
N(O)C(=O)N
InChI
1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key
VSNHCAURESNICA-UHFFFAOYSA-N
description
Merck USA index - 14, 4848
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
General description
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
Other Notes
Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
hcodes
signalword
Danger
Hazard Classifications
Muta. 1B - Repr. 2
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Melissa Seman et al.
Cell reports, 42(11), 113428-113428 (2023-11-12)
H3K9 methylation (H3K9me) marks transcriptionally silent genomic regions called heterochromatin. HP1 proteins are required to establish and maintain heterochromatin. HP1 proteins bind to H3K9me, recruit factors that promote heterochromatin formation, and oligomerize to form phase-separated condensates. We do not understand
Kaisa Ikkala et al.
Scientific reports, 12(1), 161-161 (2022-01-09)
The cornea, transparent and outermost structure of camera-type eyes, is prone to environmental challenges, but has remarkable wound healing capabilities which enables to preserve vision. The manner in which cell plasticity impacts wound healing remains to be determined. In this
P Logan Schuck et al.
The Journal of biological chemistry, 297(3), 101026-101026 (2021-08-03)
Sister chromatid cohesion (SCC), the pairing of sister chromatids after DNA replication until mitosis, is established by loading of the cohesin complex on newly replicated chromatids. Cohesin must then be maintained until mitosis to prevent segregation defects and aneuploidy. However
KMT2C-deficient tumors have elevated APOBEC mutagenesis and genomic instability in multiple cancers.
Xiaoju Hu et al.
NAR cancer, 4(3), zcac023-zcac023 (2022-07-29)
The histone methyltransferase KMT2C is among the most frequently mutated epigenetic modifier genes in cancer and plays an essential role in MRE11-dependent DNA replication fork restart. However, the effects of KMT2C deficiency on genomic instability during tumorigenesis are unclear. Analyzing
Christopher Noyes et al.
Communications biology, 6(1), 65-65 (2023-01-19)
Human cancers often re-express germline factors, yet their mechanistic role in oncogenesis and cancer progression remains unknown. Here we demonstrate that DEAD-box helicase 4 (DDX4), a germline factor and RNA helicase conserved in all multicellular organisms, contributes to increased cell
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 400046-5GMCN | 04055977212129 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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