474788
MG-132
≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem®
Synonyme(s) :
InSolution MG-132 in EtOH, ≥95% by HPLC, Proteasome Inhibitor XI
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A propos de cet article
Formule empirique (notation de Hill) :
C26H41N3O5
Poids moléculaire :
475.62
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
Service technique
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Laissez-nous vous aiderNom du produit
MG-132 in EtOH, ≥95% by HPLC, InSolution, ≥95%, reversible proteasome inhibitor
Quality Segment
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
shipped in
ambient
storage temp.
−70°C
General description
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.
Biochem/physiol Actions
Cell permeable: yes
Ki = 4 nM for proteasomal inhibition
Reversible: yes
Secondary Target
IKK
IKK
Packaging
Packaged under inert gas
Preparation Note
Following initital thaw, aliquot and freeze (-70°C).
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Flammable (J)
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
Classe de stockage
3 - Flammable liquids
wgk
WGK 2
flash_point_f
53.6 °F - closed cup - Information refers to the main component.
flash_point_c
12 °C - closed cup - Information refers to the main component.
Certificats d'analyse (COA)
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