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475956

c-Myc Inhibitor

Name: c-Myc Inhibitor
Brand: MM

≥95% (sum of two isomers, HPLC), c-Myc-Max interaction inhibitor, solid

Sinónimos:

c-Myc Inhibitor, 10058-F4, ( Z,E)-5-(4-Ethylbenzylidine)-2-thioxothiazolidin-4-one, 10058-F4, (Z,E)-5-(4-Ethylbenzylidine)-2-thioxothiazolidin-4-one

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Fórmula empírica (notación de Hill):

C₁₂H₁₁NOS₂

Número CAS:

403811-55-2

Peso molecular:

249.35

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00758517

Assay:

≥95% (sum of two isomers, HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Propiedades

Nombre del producto

c-Myc Inhibitor, The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.

Quality Segment

100

assay

≥95% (sum of two isomers, HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

S1\C(=C\c2ccc(cc2)CC)\C(=O)NC1=S

InChI

1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

InChI key

SVXDHPADAXBMFB-JXMROGBWSA-N

Descripción

General description

A cell-permeable thiazolidinone compound that specifically inhibits the c-Myc-Max interaction, thereby preventing the transactivation of c-Myc target gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).

A cell-permeable, thiazolidinone compound that specifically inhibits c-Myc-Max interaction, thereby preventing the transactivation of c-Myc targeted gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (Effective concentration: 64 µM using c-Myc-transfected Rat1a fibroblasts).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
c-Myc

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yin, X., et al. 2003. Oncogene22, 6151.

Legal Information

Sold under license of U.S. Patent 7,026,343.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

pictograms

GHS07

signalword

Warning

hcodes

H317,H319

pcodes

P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c