5.04120
Reboxetine Mesylate
別名:
Reboxetine Mesylate, (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine methanesulfonate, Edronax, Vestra
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この商品について
実験式（ヒル表記法）:
C19H23NO3 · xCH4O3S
CAS番号:
分子量:
313.39 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥99% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
color
white
solubility
water: 20 mg/mL
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(O)C.N1C[C@@H](OCC1)[C@H](Oc3c(cccc3)OCC)c2ccccc2
InChI
1S/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1
InChI key
CGTZMJIMMUNLQD-STYNFMPRSA-N
General description
A potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and >10000 nM for rat NET, SERT and DAT, respectively). Displays >1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.
Biochem/physiol Actions
Primary Target
Noradrenalin transporter
Noradrenalin transporter
Target Ki: 1.1, 129 and >10000 nM for rat NET, SERT and DAT respectively
Preparation Note
Following reconstitution, aliquot and freeze 9-20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sacchetti, G., et al. 1999. Br. J. Pharmacol.128, 1332.
Wong, E., et al. 2000. Biol. Psychiatry.47, 818.
Millan, M., et al. 2001. J. Pharmacol. Exp. Ther.298,565.
Owen, J., et al. 2003 Neurosci. Lett.348, 171.
Wong, E., et al. 2000. Biol. Psychiatry.47, 818.
Millan, M., et al. 2001. J. Pharmacol. Exp. Ther.298,565.
Owen, J., et al. 2003 Neurosci. Lett.348, 171.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable