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506106

p21-Activated Kinase Inhibitor III, IPA-3

Name: p21-Activated Kinase Inhibitor III, IPA-3
Brand: MM

The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sinónimos:

p21-Activated Kinase Inhibitor III, IPA-3, 2,2ʹ-Dihydroxy-1,1ʹ-dinaphthyldisulfide, PAK Inhibitor III

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Fórmula empírica (notación de Hill):

C₂₀H₁₄O₂S₂

Número CAS:

42521-82-4

Peso molecular:

350.45

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00388917

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Propiedades

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 10 mg/mL, ethanol: 2 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

S(Sc3c4c(ccc3O)cccc4)c1c2c(ccc1O)cccc2

InChI

1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H

InChI key

RFAXLXKIAKIUDT-UHFFFAOYSA-N

Descripción

General description

A cell-permeable symmetrical disulfide allosteric inhibitor that selectively targets the autoregulatory domain of group I, but not group II, PAKs (p21-activated kinases) and prevents the activation of PAK1/2/3 (% inhibition= 95, 70, and 60, respectively, with 10 µM inhibitor; IC₅₀ = 2.5 µM for PAK1). Specificity test shows ≥ 50% inhibition, in the presence of 10 µM ATP and inhibitor, against 9 of 214 non-PAK human kinases. Shown to effectively suppress both basal and PDGF-induced PAK activation at 30 µM in mouse embryonic fibroblasts. IPA-3 does not inhibit the enzymatic activity of preactivated PAKs and reduction of the intramolecular disulfide bond of IPA-3 by DTT renders it inactive.

Packaging

Packaged under inert gas

Other Notes

Deacon, S.W., et al. 2008. Chem. Biol.15, 322.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

pictograms

GHS05,GHS09

signalword

Danger

hcodes

H318,H410

pcodes

P273 - P280 - P305 + P351 + P338 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c