5.06125
Paroxetine Hydrochloride
別名:
Paroxetine Hydrochloride, 5-HT transporter, Paroxetine, Paxil
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
実験式（ヒル表記法）:
C19H20FNO3 · xHCl
CAS番号:
分子量:
329.37 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
solid
potency
0.065 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: soluble
storage temp.
2-8°C
SMILES string
Fc1ccc(cc1)[C@H]2[C@@H](CNCC2)COc3cc4c(cc3)OCO4
InChI
1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
InChI key
AHOUBRCZNHFOSL-YOEHRIQHSA-N
General description
A very potent uptake inhibitor highly selective for 5-HT transporter (Ki = 0.065 nM and 0.05 nM for human and rat 5-HT transporters, respectively). A popular antidepressant drug of the SSRI type. Used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms.
Biochem/physiol Actions
Primary Target
5-HT Uptake Transporter
5-HT Uptake Transporter
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Brittain, G., et al. 2012. Profiles of drug substances, excipients, and related methodology.38, 407.
Bourin, M., et al. 2001. CNS Drug Rev.7, 25.
Thomas, R., et al. 1997. Psychopharmacology (Berl).93, 193.
Bourin, M., et al. 2001. CNS Drug Rev.7, 25.
Thomas, R., et al. 1997. Psychopharmacology (Berl).93, 193.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
注意喚起語
Warning
ハザードコード
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
保管分類
11 - Combustible Solids
WGK
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable